52601-74-8

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 112-24-3 triethylentetramine 
• 4439-20-7 N,N'-bis(2-hydroxyethyl)ethylene diamine 
• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 56234-52-7 1,8-bis(p-toluenesulfonyloxy)-3,6-bis(p-toluenesulfonyl)-3,6-diazaoctane 
• 52601-80-6 N,N’,N”-tris(p-toluenesulfonyl)diethylenetriamine N,N-disodium salt 
• 56187-06-5 disodium 1,4,7,10-tetrakis(p-tolylsulfonyl)-1,4,7,10-tetraazadecane-N,N'''-diide 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 55442-07-4 N,N',N'',N'''-tetrakis-(p-tolylsulphonyl)-triethylenetetramine 

Downstream Products

• 295-64-7 pentaaza-15-crown-5 

Relevant academic research and scientific papers

Synthetic, Kinetic, and Stereochemical Studies on the Copper(II), Nickel(II), and Cobalt(III) Complexes of 1,4,7,10,13-Penta-azacyclopentadecane

The preparation of the title quinquedentate macrocyclic ligand, L, is described.The complexes 2, 2, and 2 have been prepared and characterised.The complexes can have three possible configuration as a result of the t

Expanding and quantifying the crystal chemistry of the flexible ligand 15aneN5

Tetraazamacrocycles have been very extensively exploited as transition metal ligands for a variety of purposes, including catalysis, medical imaging, pharmaceuticals, etc. However, the pentaazamacrocycles are much less commonly used for similar purposes because of poor availability, difficulties in their synthesis, and less well-known metal coordination properties. 1,4,7,10,13-pentaazacyclopentadane (15aneN5) was initially synthesized by a published synthetic route, which we simplified and shortened with minimal drop in yield. Eight different transition metal complexes were made using typical complexation methods. X-ray crystallography of multiple novel complexes yielded insight into the flexibility in coordination geometry of this interesting macrocycle as well as the first crystal structures of 15aneN5 with Cr3+, Mn3+, Fe3+, Co3+, Cu2+, and Ru2+. A parameter to quantify the coordination geometry adopted by the ligand was devised and applied to all known crystal structures of its metal complexes. Finally, oxidation of 15aneN5 to a novel diimine macrocycle was observed during complexation with ruthenium. This journal is

Synthesis of N-quaternary ammonium [3H] and [(99m)Tc]Polyazamacrocycles, potential radiotracers for cartilage imaging

The [3H] and [(99m)Tc] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [(99m)Tc]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20-25 MBq/μmol.

Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

A convenient synthesis of 1,4,7,10,13-pentaazacyclopentadecane

Cyclic pentamine 1 was synthesized in good yields from fragments containing two and three nitrogen atoms.

Methods of preparing manganese complexes of nitrogen-containing macrocyclic ligands

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

MACROHETEROCYCLES. 15.* SYNTHESIS OF MACROCYCLIC POLYAMINES IN A BIPHASIC SYSTEM

Macrocyclic polyamines are conveniently synthesized by condensation of bissulfonamides with ditosylates or dibromides of glycols in the biphasic system toluene(xylene)-aqueous sodium hydroxide.

Copper(II) and Nickel(II) Complexes of Pentaaza Macrocyclic Ligands

The preparations of the pentaazamacrocyclic ligands 1,4,7,10,13-pentaazacyclopentadecane, cpad, 1,4,7,10,13-pentaazacyclohexadecane, ched, 1,4,7,10,14-pentaazacycloheptadecane, chad, 1,4,7,11,14-pentaazacycloheptadecane, chbd, 1,4,7,11,15-pentaazacyclooctadecane, coad, 1,4,8,11,15-pentaazacyclooctadecane, cobd, 1,4,8,12,16-pentaazacyclononadecane, cnad, and 1,5,9,13,17-pentaazacycloeicosane, ceic, as well as the new linear pentaamine N-(3-aminopropyl)-N'-propyl>propane-1,3-diamine, tpah, are described.Copper(II) and nickel(II) complexes of the a bove ligands have been prepared and characterized.The nickel(II) complexes of the smaller macrocycles and the linear pentaamine contain NiII in a tetragonally distorted octahedral environment in the presence of coordinating anions or in aqueous solution but the 2+ and 2+ cations are five-coordinate both in the solid state and in aqueous solution.The copper(II) complexes of the macrocyclic pentaamines appear to be square-pyramidal on the basis of their electronic spectra, whereas the complex 2+ is probably trigonal-bipyramidal.

Synthesis of macrocyclic polyamines: Application to the increase of urinary excretion of copper in rats

The properties of six chelating agents that form highly stable complexes with transition metals has been examined in a comparative study for the elimination of copper in rats. For cyclic ligands, effectiveness grows with the stability constants of their complexes with this metal. With respect to Trien L5 and Penicillamine L6, aliphalic ligands used in human therapy the 1,4,7,10,13-pentaazacyclopentadecane has proven to be more effective. After treatment by this macrocyclic polyamine, urinary excretion reached 60 times that observed in the control animals. The acute toxicity measurements in mice demonstrated that the intrinsically slightly toxic ligands are less so than their corresponding complexes. Considered in their entirety these results, with L2, permit the inference of an improvement in Wilson's disease therapy.