52834-75-0Relevant academic research and scientific papers
Enzyme-promoted kinetic resolution of acetoxymethyl aryl sulfoxides
Kwiatkowska, Ma?gorzata,Janicki, Ignacy,Kie?basiński, Piotr
, p. 23 - 28 (2015)
A simple and efficient method of the synthesis of enantiomerically enriched, unknown acetoxymethyl aryl sulfoxides has been developed which is based on an enzyme-catalyzed hydrolysis of racemic substrates under the kinetic resolution conditions. The hydro
Electrochemical Oxidation Enables Regioselective and Scalable α-C(sp3)-H Acyloxylation of Sulfides
Wang, Huamin,He, Meng,Li, Yongli,Zhang, Heng,Yang, Dali,Nagasaka, Masanari,Lv, Zongchao,Guan, Zhipeng,Cao, Yangmin,Gong, Fengping,Zhou, Zhilin,Zhu, Jingyun,Samanta, Supravat,Chowdhury, Abhishek Dutta,Lei, Aiwen
supporting information, p. 3628 - 3637 (2021/04/07)
A highly selective, environmentally friendly, and scalable electrochemical protocol for the construction of α-acyloxy sulfides, through the synergistic effect of self-assembly-induced C(sp3)-H/O-H cross-coupling, is reported. It features exceptionally broad substrate scope, high regioselectivity, gram-scale synthesis, construction of complex molecules, and applicability to a variety of nucleophiles. Moreover, the soft X-ray absorption technique and a series of control experiments have been utilized to demonstrate the pivotal role of the self-assembly of the substrates, which indeed is responsible for the excellent compatibility and precise control of high regioselectivity in our electrochemical protocol.
Gold-Catalyzed, Iodine(III)-Mediated Direct Acyloxylation of the Unactivated C(sp3)–H Bonds of Methyl Sulfides
Guo, Sheng-rong,Santhosh Kumar, Pailla,Yuan, Yan-qin,Yang, Ming-hua
, p. 4260 - 4264 (2016/09/14)
The gold-catalyzed, iodine(III)-mediated direct oxidative acyloxylation of the C(sp3)–H bonds of methyl sulfides for the synthesis of various α-thioaryl and α-thioalkyl ester derivatives was discovered. Bis(acyloxy)iodobenzene proved to be an efficient reagent to activate the sulfur atom as an in situ directing group for α-C(sp3)–H functionalization. The attractive features of this protocol include short reaction times, low catalyst loading, and in situ activation of adjacent C(sp3)–H bonds of the sulfur atom.
Direct α-acyloxylation of organic sulfides with the hypervalent (diacyloxyiodo)benzene/tetra-n-butylammonium bromide (TBAB) reagent combination
Zhu, Dan,Chang, Denghu,Gan, Shaoyan,Shi, Lei
, p. 27983 - 27987 (2016/04/04)
A novel metal-free approach to directly synthesize α-acyloxy sulfides from readily available alkyl sulfides utilizing the hypervalent (diacyloxyiodo)benzene and TBAB reagent combination is reported. This transformation is characterized by its broad substrate scope in moderate to excellent yields, convenient operating conditions and outstanding functional group tolerance.
