52898-51-8

Basic information

• Product Name: N-methoxy-N-methyl-4-nitrobenzamide
• Synonyms: N-methoxy-N-methyl-4-nitrobenzamide
• CAS NO: 52898-51-8
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.1867
• Mol File: 52898-51-8.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-methoxy-N-methyl-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-N-methyl-4-nitrobenzamide(52898-51-8)
• EPA Substance Registry System: N-methoxy-N-methyl-4-nitrobenzamide(52898-51-8)

Safety Data

• Hazardous Substances Data: 52898-51-8(Hazardous Substances Data)

Usage

General Description

N-methoxy-N-methyl-4-nitrobenzamide is a chemical compound with the molecular formula C9H10N2O4. It is a derivative of 4-nitrobenzamide, with a methoxy and a methyl group attached to the nitrogen atom. N-methoxy-N-methyl-4-nitrobenzamide is used in the synthesis of various pharmaceuticals and agrochemicals, and it has been studied for its potential biological activities, particularly in the fields of medicine and agriculture. N-methoxy-N-methyl-4-nitrobenzamide is known for its nitro group, which can affect its reactivity and properties, and it may have applications in drug development and crop protection. Overall, this compound has potential uses in various industries and research fields due to its unique molecular structure and properties.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 619-73-8 4-nitrobenzyl chloride 
• 25393-54-8 N-(4-nitrobenzoyl)oxazolidinone 
• 32848-23-0 para-nitrophenyl perfluorobutanesulfonate 
• 13939-06-5 molybdenum hexacarbonyl 
• 586-78-7 para-nitrophenyl bromide 
• 15226-74-1 dicobalt octacarbonyl 
• 62-23-7 4-nitro-benzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 29829-22-9 S-methyldibenzothiophenium tetrafluoroborate 

Downstream Products

• 555-16-8 4-nitrobenzaldehdye 
• 765287-09-0 4,4-diethoxy-1-(4-nitrophenyl)but-2-yn-1-one 
• 619-72-7 4-nitrobenzonitrile 
• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 51207-98-8 N-butyl-4-nitrobenzamide 
• 89100-22-1 (4-nitrophenyl)(4-(-trifluoromethyl)phenyl)methanone 
• 16208-23-4 2,2‐dichloro‐1‐(4‐nitrophenyl)ethan‐1‐one 
• 2585-23-1 N-methyl-4-nitrobenzamide 
• 1599529-10-8 (1-methyl-1H-imidazol-5-yl)(4-nitrophenyl)methanone 
• 1599529-31-3 (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-30-2 (2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-11-9 (4-aminophenyl)(1-methyl-1H-imidazol-5-yl)methanone 

Relevant articles and documents

Annulation-retro-Claisen cascade of bifunctional peroxides for the synthesis of lactone natural products

A new and highly efficient annulation-retro-Claisen cascade, which involves the [4 + 1] or [5 + 1] annulation of α-benzoylacetates with bielectrophilic peroxides and a subsequent debenzoylation process under mild basic conditions, has been developed for the rapid construction of valuable tetrahydrofuran- and dihydropyran-2-carboxylates in good yields. By employing the new reaction, the unified total synthesis of γ- and δ-lactone natural products such as (±)-tanikolide, (±)-goniothalamins, (±)-7-epi-goniodiol, and (±)-plakolide A has been accomplished in 4-7 steps.

A CO2-Catalyzed Transamidation Reaction

Transamidation reactions are often mediated by reactive substrates in the presence of overstoichiometric activating reagents and/or transition metal catalysts. Here we report the use of CO2as a traceless catalyst: in the presence of catalytic amounts of CO2, transamidation reactions were accelerated with primary, secondary, and tertiary amide donors. Various amine nucleophiles including amino acid derivatives were tolerated, showcasing the utility of transamidation in peptide modification and polymer degradation (e.g., Nylon-6,6). In particular,N,O-dimethylhydroxyl amides (Weinreb amides) displayed a distinct reactivity in the CO2-catalyzed transamidation versus a N2atmosphere. Comparative Hammett studies and kinetic analysis were conducted to elucidate the catalytic activation mechanism of molecular CO2, which was supported by DFT calculations. We attributed the positive effect of CO2in the transamidation reaction to the stabilization of tetrahedral intermediates by covalent binding to the electrophilic CO2

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