529-96-4

Basic information

• Product Name: PYRIDOXAMINE-5'-PHOSPHATE
• Synonyms: 4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanoalpha-(dihydrogenphos;4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanolalpha-(dihydrogenphosp;hate);phate);pyridoxamine,3-(dihydrogenphosphate);pyridoxamine,dihydrogenphosphate;pyridoxamine-p;pyridoxaminephosphate
• CAS NO: 529-96-4
• Molecular Formula: C₈H₁₃N₂O₅P
• Molecular Weight: 248.17
• EINECS: 208-471-6
• Mol File: 529-96-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 607.3°Cat760mmHg
• Flash Point: 321.1°C
• Appearance: /
• Density: 1.559g/cm³
• PKA: pKa 8.61(H2O t = 25 I = 0.15)(Approximate)
• BRN: 233653
• CAS DataBase Reference: PYRIDOXAMINE-5'-PHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDOXAMINE-5'-PHOSPHATE(529-96-4)
• EPA Substance Registry System: PYRIDOXAMINE-5'-PHOSPHATE(529-96-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 2
• RTECS: UT4710000
• F: 3-10
• Hazardous Substances Data: 529-96-4(Hazardous Substances Data)

Usage

Uses

Pyridoxamine-5''-phosphate is a chromophore that plays a crucial role in the biosynthesis of deoxysugars (e.g. 2-Deoxy-2-chloro-D-glucose [D232570]). Pyridoxamine-5''-phosphate is naturally found in rat liver.

Definition

ChEBI: A vitamin B6 phosphate that is the phosphoric ester derivative of pyridoxamine.

General Description

Pyridoxamine is a derivative of vitamin B6. Pyridoxamine is a water-soluble vitamin. Vitamin B6 derivatives contain a core pyridine ring. Pyridoxaminecontains an amino methyl group at pyridine′s 4′ position.

Biochem/physiol Actions

pK of pyridoxamine-5′-phosphate (pyridoxamine 5-phosphate, PAMP) in the singlet excited state has been evaluated by absorption and fluorescence spectral studies.

Upstream product

• 54-47-7 pyridoxal 5'-phosphate 
• 110139-25-8 N-Dodecyl-(S)-alaninamide 
• 56-86-0 L-glutamic acid 
• 7758-99-8 copper(II) sulfate 
• 32653-39-7 C₁₃H₁₉N₂O₇P 
• 17280-36-3 C₁₂H₁₅N₂O₉P 
• 35314-38-6 C₁₉H₂₀N₃O₇P 
• 21888-14-2 C₁₃H₁₇N₂O₉P 
• 58-56-0 pyridoxal hydrochloride 
• 20905-66-2 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine oxime 
• 61-90-5 L-leucine 
• 57-50-1 Sucrose 
• 3458-28-4 D-Mannose 
• 2280-44-6 D-Glucose 

Downstream Products

• 85-87-0 pyridoxamine 
• 954-27-8 4-pyridoxic acid 5'-phosphate 
• 54-47-7 pyridoxal 5'-phosphate 

Relevant articles and documents

Production of pyridoxal phosphate by a mutant strain of Schizosaccharomyces pombe.

Conditions for extracellular production of vitamin B6 compounds (B6), especially pyridoxal 5'-phosphate (PLP) by Schizosaccharomyces pombe leul strain were examined. The productivity was dependent on concentration of L-leucine in the culture medium: 30 mg/l gave the highest concentrations of total B6 and PLP. The viable cells harvested at different growth phases showed different productivity: middle and late exponential phase cells showed the highest productivity of total B6 and PLP, respectively. D-Glucose (1%, w/v) among other sugars gave the best productivity. Supplementation of air and ammonium sulfate significantly increased extracellular production of PLP. Superoxide anion producers, menadione and plumbagin, and H202 increased the productivity of PLP. Cycloheximide inhibited the increase of PLP by the oxidative stress and, in contrast, increased pyridoxine.

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Chemical transformations of pyridoxal and pyridoxal 5′-phosphate condensation products with amino acids

The mechanism of chemical transformations of pyridoxal and pyridoxal 5′-phosphate condensation products with amino acids is studied by kinetic measurements. The Schiff bases are shown to be fairly stable in neutral media. In acid media, the Schiff bases a