5292-23-9

Basic information

• Product Name: 3-(4-chlorophenyl)butanoic acid
• CAS NO: 5292-23-9
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.6461
• Mol File: 5292-23-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 311.3°C at 760 mmHg
• Flash Point: 142.1°C
• Density: 1.221g/cm³
• Vapor Pressure: 0.000243mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 3-(4-chlorophenyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)butanoic acid(5292-23-9)
• EPA Substance Registry System: 3-(4-chlorophenyl)butanoic acid(5292-23-9)

Safety Data

• Hazardous Substances Data: 5292-23-9(Hazardous Substances Data)

Upstream product

• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 201230-82-2 carbon monoxide 
• 625-38-7 but-3-enoic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 21758-07-6 3-(4-chloro-phenyl)-crotonic acid 
• 124-38-9 carbon dioxide 
• 1243130-08-6 ethyl 3-methyl-3-p-chlorophenylpropionate 
• 64-18-6 formic acid 
• 1864-94-4 phenyl formate 
• 14804-61-6 1-(1-bromoethyl)-4-chlorobenzene 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 153805-70-0 (Z)-ethyl 4-bromo-3-(4-chlorophenyl)but-2-enoate 
• 21757-98-2 ethyl (E)-3-(4-chlorophenyl)-2-butenoate 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 

Downstream Products

• 54795-05-0 6-Chlor-3-methylindanon 

Relevant articles and documents

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Exploration of New Biomass-Derived Solvents: Application to Carboxylation Reactions

A range of hitherto unexplored biomass-derived chemicals have been evaluated as new sustainable solvents for a large variety of CO2-based carboxylation reactions. Known biomass-derived solvents (biosolvents) are also included in the study and the results are compared with commonly used solvents for the reactions. Biosolvents can be efficiently applied in a variety of carboxylation reactions, such as Cu-catalyzed carboxylation of organoboranes and organoboronates, metal-catalyzed hydrocarboxylation, borocarboxylation, and other related reactions. For many of these reactions, the use of biosolvents provides comparable or better yields than the commonly used solvents. The best biosolvents identified are the so far unexplored candidates isosorbide dimethyl ether, acetaldehyde diethyl acetal, rose oxide, and eucalyptol, alongside the known biosolvent 2-methyltetrahydrofuran. This strategy was used for the synthesis of the commercial drugs Fenoprofen and Flurbiprofen.

Two-carbon ring expansion of 1-indanones via insertion of ethylene into carbon-carbon bonds

A rhodium-catalyzed direct insertion of ethylene into a relatively unstrained carbon-carbon bond in 1-indanones is reported, which provides a two-carbon ring expansion strategy for preparing seven-membered cyclic ketones. As many 1-indanones are commercially available and ethylene is inexpensive, this strategy simplifies synthesis of benzocycloheptenones that are valuable synthetic intermediates for bioactive compounds but challenging to prepare otherwise. In addition, the reaction is byproduct-free, redox neutral, and tolerant of a wide range of functional groups, which may have implications on unconventional strategic bond disconnections for preparing complex cyclic molecules.