531-26-0

Basic information

• Product Name: 4-allyl-2-methoxyphenyl benzoate
• Synonyms: 4-allyl-2-methoxyphenyl benzoate;EUGENOL BENZOATE;Phenol, 2-methoxy-4-(2-propenyl)-, benzoate;benzoyleugenol;2-Methoxy-4-(2-propenyl)phenol benzoate;Benzoic acid 2-methoxy-4-(2-propenyl)phenyl ester;(2-methoxy-4-prop-2-enylphenyl) benzoate;(2-methoxy-4-prop-2-enyl-phenyl) benzoate
• CAS NO: 531-26-0
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.30714
• EINECS: 208-504-4
• Mol File: 531-26-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 360 °C at 760 mmHg
• Flash Point: 181.3 °C
• Appearance: /
• Density: 1.112 g/cm³
• Vapor Pressure: 2.29E-05mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 4-allyl-2-methoxyphenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-allyl-2-methoxyphenyl benzoate(531-26-0)
• EPA Substance Registry System: 4-allyl-2-methoxyphenyl benzoate(531-26-0)

Safety Data

• Hazardous Substances Data: 531-26-0(Hazardous Substances Data)

Usage

Chemical Properties

Eugenyl benzoate has a balsamic odor with an undertone reminiscent of clove.

InChI:InChI=1/C17H16O3/c1-3-7-13-10-11-15(16(12-13)19-2)20-17(18)14-8-5-4-6-9-14/h3-6,8-12H,1,7H2,2H3

Upstream product

• 97-53-0 4-allylguaiacol 
• 98-88-4 benzoyl chloride 
• 10533-83-2 N-benzoyl-N-methyl-4-methylbenzenesulfonamide 
• 85909-02-0 N-benzyl-N-(tert-butoxycarbonyl)-benzamide 
• 65-85-0 benzoic acid 
• 97-54-1 2-methoxy-4-propenylphenol 
• 100-52-7 benzaldehyde 

Downstream Products

• 4194-00-7 (E)-2-methoxy-4-(1-propen-1-yl)phenyl benzoate 
• 112777-58-9 4-benzoyloxy-3-methoxy-benzoic acid 
• 6751-78-6 Benzoic acid 5-bromo-4-(2,3-dibromo-propyl)-2-methoxy-phenyl ester 
• 5746-35-0 4-(2,3-Dibromo-propyl)-2-methoxy-phenol 
• 6716-51-4 1-benzoyloxy-4-(2,3-dibromo-propyl)-2-methoxy-benzene 
• 872302-05-1 1-benzoyloxy-2-methoxy-4-propyl-benzene 

Relevant articles and documents

Synthesis of eugenol derivatives and its anti-inflammatory activity against skin inflammation

Eugenol is a phytochemical present in aromatic plants has generated considerable interest in the pharmaceutical industries mainly in cosmetics. A series of eugenol esters (ST1-ST7) and chloro eugenol (ST8) have been synthesized. The structures of newly synthesized compounds were confirmed by 1H and 13C NMR and mass spectrometry. In an effort to evaluate the pharmacological activity of eugenol derivatives, we explored its anti-inflammatory potential against skin inflammation using in-vitro and in-vivo bioassay. Synthesized derivatives significantly inhibited the production of pro-inflammatory cytokines against LPS-induced inflammation in macrophages. Among all derivatives, ST8 [Chloroeugenol (6-chloro, 2-methoxy-4-(prop-2-en-1-yl)-phenol)] exhibited most potent anti-inflammatory activity without any cytotoxic effect. We have further evaluated the efficacy and safety in in-vivo condition. ST8 exhibited significant anti-inflammatory activity against TPA-induced skin inflammation without any skin irritation effect on experimental animals. These findings suggested that ST8 may be a useful therapeutic candidate for the treatment of skin inflammation.

Mechanically induced solvent-free esterification method at room temperature

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)3, esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed. This journal is

Synthesis, antimicrobial activity and in silico studies on eugenol eters

The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjected to in vitro antimicrobial testing. In silico studies were carried out calculating physico-chemical, pharmacokinetic and toxicological properties, providing more data as additional guidance for further research.