5317-80-6Relevant academic research and scientific papers
Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils
Liang, Baihui,Huang, Junjie,Zhu, Weidong,Li, Yawen,Jiang, Lanping,Gao, Yang,Xie, Feng,Li, Yibiao,Chen, Xiuwen,Zhu, Zhongzhi
, p. 1466 - 1473 (2021/02/09)
A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.
Synthesis method of o-acylaniline sulfonamide compound
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Paragraph 0203-0210, (2020/10/30)
The invention discloses a synthesis method of a o-acylaniline sulfonamide compound. The preparation method is characterized by comprising the following steps: mixing a benzisoxazole compound as shownin a chemical formula I, a sodium sulfinate compound as shown in a chemical formula II, a metal catalyst and a solvent, and reacting to obtain the o-acylaniline sulfonamide compound as shown in a chemical formula III, in the formula, R1 is a monosubstituted or polysubstituted group on a benzene ring. The synthesis method can be used for efficiently synthesizing the o-acylaniline sulfonamide compound, has the advantages of simple synthesis steps, safety in operation, good compatibility of the synthesis method to functional groups and high atom economy, and is easy for industrial synthesis.
Diastereoselective synthesis of 2,4-substituted tetrahydroquinolines via hf(otf)4-catalyzed substitution/cyclization of 2-aminobenzyl alcohols with styrenes
Noji, Masahiro,Kadowaki, Hiroto,Kubota, Yuuki,Yoshida, Tomomi,Saito, Noriko,Yamaguchi, Subaru,Ohata, Ren,Ishii, Keitaro,Takanami, Toshikatsu
, p. 1041 - 1073 (2017/07/27)
An efficient and convenient stereoselective synthetic approach to 2,4-substituted 1,2,3,4-tetrahydroquinoline has been developed. This catalytic procedure involves a sequential reaction of 2-aminobenzyl alcohol with styrenes in the presence of Hf(OTf)4 ca
Iridium-catalyzed direct C-H amidation with weakly coordinating carbonyl directing groups under mild conditions
Kim, Jinwoo,Chang, Sukbok
supporting information, p. 2203 - 2207 (2014/03/21)
An iridium-catalyzed direct C-H amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives. Copyright
Synthesis and antioxidant activity of a new series of 2,1-benzothiazine 2,2-dioxide hydrazine derivatives
Shafiq, Muhammad,Khan, Islam Ullah,Zia-Ur-Rehman, Muhammad,Asghar, Muhammad Nadeem,Asiri, Abdullah M.,Arshad, Muhammad Nadeem
scheme or table, p. 4799 - 4803 (2012/08/08)
A convenient synthesis of a series of new N-benzylidene-N'-(1-ethyl-2, 2-dioxo-2,3-dihydro-1H-2λ6-benzo[c][1,2]thiazin-4-ylidene) -hydrazines is reported. The starting compound methyl anthranilate was reacted with methane sulfonyl chloride, fol
Synthesis of novel anti-bacterial 2,1-benzothiazine 2,2-dioxides derived from methyl anthranilate
Shafiq, Muhammad,Zia-Ur-Rehman, Muhammad,Khan, Islam Ullah,Arshad, Muhammad Nadeem,Khan, Siraj Ahmed
experimental part, p. 527 - 531 (2012/04/23)
A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2?6-benzo[c][1,2]thiazin-4- ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfon
β-cyclodextrin-catalyzed monosulfonylation of amines and amino acids in water
Sridhar,Srinivas,Kumar, V. Pavan,Narender,Rao, K. Rama
, p. 1873 - 1876 (2008/09/16)
A mild and efficient procedure has been developed for the first time under biomimetic conditions for the monosulfonylation of various amines and amino acids catalyzed by β-cyclodextrin in water at room temperature to afford the corresponding sulfonamides in high yields.
COX-1/COX-2 inhibitors based on the methanone moiety
Dannhardt, Gerd,Fiebich, Bernd L,Schweppenhaeuser, Johannes
, p. 147 - 161 (2007/10/03)
This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors. Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl methanone element was chosen as a lead. Modifications were carried out on this scaffold to obtain potent inhibitors of the COX enzymes. The N-(2-aroylphenyl)sulphonamides and -amides were studied in detail, and to consolidate the data evaluated the corresponding 3- and 4-regioisomers were also investigated. The potency and the enzyme selectivity were varied by structural modifications of the lead.
