53205-66-6

Basic information

• Product Name: N-cyclohexyl-3-methylbenzamide
• Synonyms: N-cyclohexyl-3-methylbenzamide
• CAS NO: 53205-66-6
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.30676
• Mol File: 53205-66-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 369.9°Cat760mmHg
• Flash Point: 223°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: N-cyclohexyl-3-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-3-methylbenzamide(53205-66-6)
• EPA Substance Registry System: N-cyclohexyl-3-methylbenzamide(53205-66-6)

Safety Data

• Hazardous Substances Data: 53205-66-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H19NO/c1-11-6-5-7-12(10-11)14(16)15-13-8-3-2-4-9-13/h5-7,10,13H,2-4,8-9H2,1H3,(H,15,16)

Upstream product

• 110-83-8 cyclohexene 
• 1919-46-6 2,4,6-tris-m-tolyloxy-[1,3,5]triazine 
• 3173-53-3 Cyclohexyl isocyanate 
• 443638-87-7 N-(3-methylbenzoyl)-8-aminoquinoline 
• 108-91-8 cyclohexylamine 
• 618-47-3 m-toluamide 
• 110-82-7 cyclohexane 
• 201230-82-2 carbon monoxide 
• 625-95-6 3-Iodotoluene 
• 931-53-3 Cyclohexyl isocyanide 
• 108-41-8 1-chloro-3-methylbenzene 
• 13144-62-2 2-(cyclohexylamino)-2-oxoacetic acid 
• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 

Relevant articles and documents

Secondary amide-based linkers for solid phase organic synthesis

The electron rich benzaldehyde derivatives 4-hydroxybenzaldehyde and 2-methoxy-4-hydroxybenzaldehyde have been investigated for use as linkers for solid phase organic synthesis. Reductive amination of these aldehydes attached to ArgoGel resins with a model primary amine gave the corresponding benzylic secondary amines. These compounds were then converted to the corresponding ureas, sulfonamides, aryl amides, and alkyl amides by derivatization with an appropriate electrophile. The desired secondary amide derivative was then cleaved from the support by treatment with trifluoroacetic acid to provide essentially quantitative yields of products in high purity.

Nickel-catalyzed reductive amidation of aryl-triazine ethers

The reaction of activated phenolic compounds, 2,4,6-triaryloxy-1,3,5-triazine (aryl-triazine ethers), with various isocyanates or carbodiimides in the presence of a nickel pre-catalyst resulted in the synthesis of aryl amides in good to excellent yields.

Amide Boc de-protection method

The invention discloses an amide Boc de-protection method. The amide Boc de-protection method includes carrying out reaction on Boc protected amide III and amine IV under the condition of the presenceof palladium catalysts to generate new amide V. 8-aminoquinoline can be used as a guide group to be applied to chemical reaction, a process for synthesizing the new amide by means of de-protection isprovided, protecting groups can be easily removed by means of palladium catalysis, the new amide can be generated, and the reaction is high in efficiency. The amide Boc de-protection method has the advantages of environmental friendliness, recyclability and the like.