5326-06-7Relevant articles and documents
Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa
Alissa, Siham A.,Alghulikah, Hanan A.,Alothman, Zeid A.,Osman, Sameh M.,Del Prete, Sonia,Capasso, Clemente,Nocentini, Alessio,Supuran, Claudiu T.
, p. 59 - 64 (2019/11/11)
A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (
Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors
Nocentini, Alessio,Gratteri, Paola,Supuran, Claudiu T.
, p. 1188 - 1192 (2019/01/04)
The first zinc-binding group (ZBG) to have been identified as inhibitor of the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1) was the sulfonamide. From then on several classes of zinc-binders have been described. This work reports the benzenephospon
PHOSPHORUS ANALOGUES OF AMINO ACIDS AND PEPTIDES XII. REACTION OF SODIUM DIETHYL PHOSPHITE WITH AROMATIC ALDAZINES AND HYDRAZONES
Topolski, M.,Rachon, J.
, p. 97 - 110 (2007/10/02)
The mechanism of the reaction of sodium diethyl phosphite with aromatic aldazines has been investigated.The initially formed monoaddition product (4) reacts with the excess of phosphorus reagent prior to the conceivable addition of diethyl phosphite to the C=N double bond.Cleavage of the N-N single bond is initiated by Single Electron Transfer from phosphite anion to the conjugated N=CH-Ph bond system.The scope of the reaction can be extended to other aromatic hydrazones.There is strong evidence to support the operation of a non-chain SET mechanism.
