78133-05-8

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 64-17-5 ethanol 
• 14360-83-9 tetraphenyl-cyclodiphosphazane-2,4-dioxide 
• 62-53-3 aniline 
• 5284-12-8 ethyl chloro(phenyl)phosphinate 
• 4129-17-3 diphenylphosphoranyl azide 
• 172487-18-2 ethyl Phenylphosphinate 
• 622-37-7 Phenyl azide 
• 5326-06-7 Phenylphosphonic acid monoethyl ester amide 
• 59-88-1 phenylhydrazine hydrochloride 
• 108-86-1 bromobenzene 
• 1638-86-4 diethyl phenylphosphonite 
• 4546-19-4 ethyl hydrogen phenylphosphonate 

Downstream Products

• 1454908-30-5 C₁₈H₂₀NO₄P 
• 1496564-26-1 C₁₄H₁₅⁽²⁾HNO₂P 

Relevant academic research and scientific papers

Ligand-free copper-catalyzed denitrogenative arylation of phosphorylamides with arylhydrazines

A straightforward arylation of phosphorylamides with arylhydrazines hydrochloride was herein demonstrated. The protocol proceeded in the presence of a catalytic loading of Cu(OAc)2 as the catalyst, DTBP as the external oxidant and Cs2CO3 as the base, but without any ligands. And a series of N-aryl phosphorylamides were successfully obtained in high efficiency (up to 93% yields) with good substituents compatibility (up to 30 examples). Free radical mechanism was proposed for the facile methodology based on the results of control reactions and literature explorations.

Efficient Synthesis of Phosphonamidates through One-Pot Sequential Reactions of Phosphonites with Iodine and Amines

A one-pot sequential strategy to construct phosphonamidates has been developed by generating phosphonites in situ from arylmagnesium bromides and triethyl phosphite followed by treatment with iodine and amines. A variety of phosphonamidates were obtained with good to excellent yields at room temperature from easily available materials.

Rhodium-catalyzed oxidative coupling through C-H activation and annulation directed by phosphonamide and phosphinamide groups

Rhodium-catalyzed oxidative coupling reactions via C-H activation and annulation directed by phosphonamide and phosphinamide groups were developed under aerobic conditions, which produced benzazaphosphole 1-oxides and phosphaisoquinolin-1-oxides.

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

PHOTOLYTIC REARRANGEMENT OF PHOSPHORUS AZIDE : EVIDENCE FOR A TRANSIENT METAPHOSPHONIMIDATE.

Photolysis of the oxide of diphenylphosphine azide gives rise to a transient metaphisphonimidate, a new tricoordinated pentavalent phosphorus compound.Evidence for this species was given by trapping reactions on a variety of substrates.