78133-05-8

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 64-17-5 ethanol 
• 14360-83-9 tetraphenyl-cyclodiphosphazane-2,4-dioxide 
• 62-53-3 aniline 
• 5284-12-8 ethyl chloro(phenyl)phosphinate 
• 172487-18-2 ethyl Phenylphosphinate 
• 622-37-7 Phenyl azide 
• 108-86-1 bromobenzene 
• 1638-86-4 diethyl phenylphosphonite 
• 5326-06-7 Phenylphosphonic acid monoethyl ester amide 
• 59-88-1 phenylhydrazine hydrochloride 
• 4546-19-4 ethyl hydrogen phenylphosphonate 
• 4129-17-3 diphenylphosphoranyl azide 

Downstream Products

• 1454908-30-5 C₁₈H₂₀NO₄P 
• 1496564-26-1 C₁₄H₁₅⁽²⁾HNO₂P 

Relevant academic research and scientific papers

Efficient Synthesis of Phosphonamidates through One-Pot Sequential Reactions of Phosphonites with Iodine and Amines

A one-pot sequential strategy to construct phosphonamidates has been developed by generating phosphonites in situ from arylmagnesium bromides and triethyl phosphite followed by treatment with iodine and amines. A variety of phosphonamidates were obtained with good to excellent yields at room temperature from easily available materials.

Ligand-free copper-catalyzed denitrogenative arylation of phosphorylamides with arylhydrazines

A straightforward arylation of phosphorylamides with arylhydrazines hydrochloride was herein demonstrated. The protocol proceeded in the presence of a catalytic loading of Cu(OAc)2 as the catalyst, DTBP as the external oxidant and Cs2CO3 as the base, but without any ligands. And a series of N-aryl phosphorylamides were successfully obtained in high efficiency (up to 93% yields) with good substituents compatibility (up to 30 examples). Free radical mechanism was proposed for the facile methodology based on the results of control reactions and literature explorations.

Rhodium-catalyzed oxidative coupling through C-H activation and annulation directed by phosphonamide and phosphinamide groups

Rhodium-catalyzed oxidative coupling reactions via C-H activation and annulation directed by phosphonamide and phosphinamide groups were developed under aerobic conditions, which produced benzazaphosphole 1-oxides and phosphaisoquinolin-1-oxides.

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

PHOTOLYTIC REARRANGEMENT OF PHOSPHORUS AZIDE : EVIDENCE FOR A TRANSIENT METAPHOSPHONIMIDATE.

Photolysis of the oxide of diphenylphosphine azide gives rise to a transient metaphisphonimidate, a new tricoordinated pentavalent phosphorus compound.Evidence for this species was given by trapping reactions on a variety of substrates.