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53309-95-8

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53309-95-8 Usage

General Description

"(3E)-4-phenylbut-3-en-2-amine" is a chemical compound with the molecular formula C10H15N. It is classified as an amine, which is a type of organic compound that contains a nitrogen atom bonded to one or more carbon atoms. The compound has a phenyl group, which is a six-carbon aromatic ring, and a double bond in the butene chain. This chemical can be used as a precursor in the synthesis of various pharmaceuticals and agrochemicals, as well as in the production of polymers and other industrial materials. Additionally, it may also have potential applications in research and development for the creation of new compounds with valuable properties. Overall, the structural features and functional groups present in "(3E)-4-phenylbut-3-en-2-amine" make it a versatile and potentially useful compound for a variety of chemical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 53309-95-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,0 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53309-95:
(7*5)+(6*3)+(5*3)+(4*0)+(3*9)+(2*9)+(1*5)=118
118 % 10 = 8
So 53309-95-8 is a valid CAS Registry Number.

53309-95-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-4-phenylbut-3-en-2-amine

1.2 Other means of identification

Product number -
Other names 13-Amino-1-(buten-(11)-yl)-benzol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:53309-95-8 SDS

53309-95-8Relevant articles and documents

PQQ-dependent Dehydrogenase Enables One-pot Bi-enzymatic Enantio-convergent Biocatalytic Amination of Racemic sec-Allylic Alcohols

Gandomkar, Somayyeh,Rocha, Raquel,Sorgenfrei, Frieda A.,Montero, Lía Martínez,Fuchs, Michael,Kroutil, Wolfgang

, p. 1290 - 1293 (2020/12/23)

The asymmetric amination of secondary racemic allylic alcohols bears several challenges like the reactivity of the bi-functional substrate/product as well as of the α,β-unsaturated ketone intermediate in an oxidation-reductive amination sequence. Heading for a biocatalytic amination cascade with a minimal number of enzymes, an oxidation step was implemented relying on a single PQQ-dependent dehydrogenase with low enantioselectivity. This enzyme allowed the oxidation of both enantiomers at the expense of iron(III) as oxidant. The stereoselective amination of the α,β-unsaturated ketone intermediate was achieved with transaminases using 1-phenylethylamine as formal reducing agent as well as nitrogen source. Choosing an appropriate transaminase, either the (R)- or (S)-enantiomer was obtained in optically pure form (>98 % ee). The enantio-convergent amination of the racemic allylic alcohols to one single allylic amine enantiomer was achieved in one pot in a sequential cascade.

Sequential Two-Step Stereoselective Amination of Allylic Alcohols through the Combination of Laccases and Amine Transaminases

Albarrán-Velo, Jesús,Lavandera, Iván,Gotor-Fernández, Vicente

, p. 200 - 211 (2019/12/03)

A sequential two-step chemoenzymatic methodology for the stereoselective synthesis of (3E)-4-(het)arylbut-3-en-2-amines in a highly selective manner and under mild reaction conditions is described. The approach consists of oxidation of the corresponding racemic alcohol precursors by the use of a catalytic system made up of the laccase from Trametes versicolor and the oxy-radical TEMPO, followed by the asymmetric reductive bio-transamination of the corresponding ketone intermediates. Optimisation of the oxidation reaction, exhaustive amine transaminase screening for the bio-transaminations and the compatibility of the two enzymatic reactions were studied in depth in search of a design of a compatible sequential cascade. This synthetic strategy was successful and the combinations of enzymes displayed a broad substrate scope, with 16 chiral amines being obtained in moderate to good isolated yields (29–75 %) and with excellent enantiomeric excess values (94 to >99 %). Interestingly, both amine enantiomers can be achieved, depending on the selectivity of the amine transaminase employed in the system.

Palladium-catalyzed aerobic oxidative coupling of enantioenriched primary allylic amines with sulfonyl hydrazides leading to optically active allylic sulfones

Wang, Ting-Ting,Wang, Fu-Xiang,Yang, Fu-Lai,Tian, Shi-Kai

supporting information, p. 3802 - 3805 (2014/04/03)

A range of highly enantioenriched primary allylic amines underwent palladium-catalyzed oxidative coupling with sulfonyl hydrazides open to air at room temperature to give structurally diverse allylic sulfones in moderate to excellent yields with excellent retention of ee. This journal is the Partner Organisations 2014.

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