53391-62-1

Usage

Uses

Used in Pharmaceutical Applications:
Ethanone, 2-chloro-1-(1H-pyrrol-2-yl)(9CI) is used as a potential anticonvulsant agent for the treatment of seizure disorders. It has demonstrated promising results in animal models, indicating its potential to manage and control epileptic seizures.
Used in Research Applications:
In the field of research, Ethanone, 2-chloro-1-(1H-pyrrol-2-yl)(9CI) serves as a valuable building block in the synthesis of more complex organic compounds. Its unique structure and properties make it a useful component in the development of novel pharmaceutical agents and other advanced organic materials.
Used in Organic Synthesis:
Ethanone, 2-chloro-1-(1H-pyrrol-2-yl)(9CI) is utilized as a key intermediate in the organic synthesis of various compounds. Its reactivity and structural features allow for the creation of a wide range of molecules with diverse applications in chemistry and related industries.

InChI:InChI=1/C6H6ClNO/c7-4-6(9)5-2-1-3-8-5/h1-3,8H,4H2

Upstream product

• 109-97-7 pyrrole 
• 107-14-2 chloroacetonitrile 
• 2675-89-0 2-chloro-N,N-dimethylacetamide 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 79-04-9 chloroacetyl chloride 
• 1072-83-9 2-Acetylpyrrole 

Downstream Products

• 1417565-89-9 C₁₂H₈I₃NO₂ 
• 1417565-88-8 C₁₂H₈BrI₂NO₂ 
• 1417565-87-7 C₁₂H₈ClI₂NO₂ 
• 1417565-97-9 2-phenylbenzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1417565-85-5 C₁₄H₁₃IN₂O₃ 
• 1417565-84-4 C₁₉H₁₆INO₃ 
• 1417565-95-7 2-(benzyloxy)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1417565-83-3 C₁₆H₁₈INO₂ 
• 1417565-82-2 C₁₅H₁₆INO₂ 
• 1417565-81-1 C₁₄H₁₄INO₂ 
• 1417565-80-0 C₁₃H₁₂INO₂ 
• 1147836-19-8 2-(2-iodophenoxy)-1-(1H-pyrrol-2-yl)ethanone 
• 1072-83-9 2-Acetylpyrrole 
• 861591-86-8 2-amino-1-pyrrol-2-yl-ethanone 

Relevant academic research and scientific papers

Chemoselective Reduction of Trichloromethyl Compounds to gem-Dichloromethyl Groups Following Appel's Reaction Protocol

A simple and easy reduction of trichloroacetyl compounds following the modification of Appel's reaction protocol, using triphenylphosphine and methanol, afforded the corresponding dichloroacetyl compounds, with the exception of trichloroacetylmorpholine,

Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide

A highly efficient procedure for preparing 2-acylpyrroles and its derivatives is described. The products were obtained through regioselective Friedel-Crafts reactions of pyrroles and its derivatives with alkyl or aryl acid chlorides catalysed by zinc oxide under solvent-free conditions. This method has the advantages of green chemistry, operational simplicity, solvent-free conditions, and recoverable catalyst.

Enantioselective synthesis of heteroaromatic epoxyketones under phase-transfer catalysis using D-glucose- and D-mannose-based crown ethers

Heteroaromatic epoxyketones have been synthesized in an asymmetric Darzens condensation of 2-chloroacetylfuran or 2- and 3-chloroacetylthiophene with aromatic aldehydes and in the enantioselective epoxidation of α,β-enones with an N-methylpyrrole unit, in

Spectroscopic and theoretical studies on some new pyrrol-2-yl-chloromethyl ketones

A novel series of pyrrole-2-yl chloromethyl ketones were synthesized and studied by FT-IR, 1H, 13C NMR spectroscopy and DFT calculations at the B3LYP/6-311++G(d,p) level of approximation. Two stable conformations were detected in solution: s-cis and s-trans forms where the C=O group is located on the same side or the opposite side of N-H group, respectively. The conformational stability of these molecules is governed mainly by intermolecular hydrogen bonding interactions. The strength of hydrogen bonds was evaluated on the basis of 1H chemical shift and infrared red shift ΔνN-H of the stretching vibration of N-H proton donating bonds. The quantum theory of 'atoms in molecules' as well as the natural bond orbital method were applied to characterize hydrogen bonding interactions. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2010.

Selective α-Chlorination of Acetylpyrroles

Reaction of acetylpyrroles with benzyltrimethylammonium dichloroiodate in tetrahydrofuran solution leads to the corresponding α-chloro derivatives with high selectivity and good yields.

Direct Vilsmeier-Haack Chloroacetylation of Pyrroles

Reaction of pyrroles with N,N-dimethyl-2-chloroacetamide in the presence of phosphorus oxychloride leads to a mixture of 2- and 3-chloroacetylpyrroles, which can be separated by chromatography.