5344-20-7

Basic information

• Product Name: isohexylamine
• Synonyms: 4-methylpentan-1-amine
• CAS NO: 5344-20-7
• Molecular Formula: C₆H₁₅N
• Molecular Weight: 101.19
• Mol File: 5344-20-7.mol

Chemical Properties

• Boiling Point: 125°C at 760 mmHg
• Flash Point: 25.7°C
• Density: 0.768g/cm³
• Vapor Pressure: 12.4mmHg at 25°C
• Refractive Index: 1.42
• CAS DataBase Reference: isohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: isohexylamine(5344-20-7)
• EPA Substance Registry System: isohexylamine(5344-20-7)

Safety Data

• Hazardous Substances Data: 5344-20-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Isohexylamine is used as an intermediate in the production of pharmaceuticals for its ability to react and form various organic compounds essential in drug synthesis.
Used in Pesticide Industry:
Isohexylamine serves as an intermediate in the creation of pesticides, contributing to the development of effective agricultural chemicals.
Used in Organic Compounds Synthesis:
As an intermediate, Isohexylamine is utilized in the synthesis of other organic compounds, highlighting its role in the broader scope of chemical production.
Used as a Corrosion Inhibitor:
Isohexylamine is employed as a corrosion inhibitor, leveraging its properties to protect materials from degradation in various industrial applications.
Used in Surfactant Manufacturing:
Isohexylamine is used as an intermediate in the manufacture of surfactants, which are critical in the production of detergents, cleaners, and other products that require the reduction of surface tension.
Used in Rubber Chemical Synthesis:
Isohexylamine is utilized in the synthesis of rubber chemicals, playing a part in the creation of additives that enhance the properties of rubber products.
Used as an Industrial Solvent:
Acting as an industrial solvent, Isohexylamine is involved in the dissolution of various substances in industrial processes, facilitating chemical reactions and material treatments.
It is crucial to handle Isohexylamine with care due to its corrosive nature and potential to cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be taken to mitigate any risks associated with its use.

Upstream product

• 38136-29-7 4-methylvaleroyl chloride 
• 646-07-1 4-Methylpentanoic acid 
• 21101-88-2 3-methylpentanenitrile 
• 626-89-1 4-Methyl-1-pentanol 
• 28659-89-4 (2S)-2-bromo-4-methylpentanamide 
• 28659-88-3 chloride of/the/ L(-)-α-bromo-isocaproic acid 
• 28659-87-2 (S)-2-bromo-4-methylpentanoic acid 
• 61-90-5 L-leucine 
• 542-54-1 isocapronitrile 
• 7647-01-0 hydrogenchloride 
• 857781-97-6 isohexyl-carbamic acid ethyl ester 
• 28659-90-7 (2S)-2-bromo-4-methylpentanenitrile 
• 1119-29-5 4-methyl-pentanamide 

Downstream Products

• 108899-61-2 N-isohexyl-2,4-dinitro-aniline 
• 349098-69-7 N-(4-methylpentyl)-4-methylbenzenesulfonamide 
• 108262-66-4 5-amino-2-methylpentan-2-ol 
• 123296-19-5 N-(3-hydroxy-4-methylpentyl)benzamide 
• 881384-15-2 5-[4-(2-Trifluoromethyl-benzoyl)-piperazin-1-yl]-[1,3,4]thiadiazole-2-carboxylic acid (4-methyl-pentyl)-amide 
• 22459-47-8 N-(1-(Bicyclo<2.2.1>hepten-(5)-yl-(2))-2-phenyl-ethyl)-isohexylamin 
• 62016-94-8 2-Methylpent-5-ylchlorid 
• 853942-70-8 3-(4-methylpentyl)-4-phenyl-4-(trichloromethyl)-3,4-dihydroquinazolin-2(1H)-one 
• 22443-63-6 N-(2,5-Methylen-hexahydrobenzal)-isohexylamin 
• 22274-67-5 N-(2,5-Methylen-1,2,5,6-tetrahydro-benzal)-isohexylamin 
• 76383-69-2 2-(N,N'-Diphenyl-hydrazinocarbonyl)-hexanoic acid (4-methyl-pentyl)-amide 
• 30221-04-6 3-Benzyloxycarbonylamino-N-(4-methyl-pentyl)-succinamic acid benzyl ester 

Relevant articles and documents

Two new insecticidal amides and a new alcoholic amide from Piper nigrum LINN

Three new amides, pipgulzarine (1), pipzorine (2), and piptahsine (3), have been isolated from the dried seeds of Piper nigrum LINN. along with nine known constituents: (2E,4E,8Z)-N-(isobutyl)eicosatrienamide, pellitorine, pipercide, piperine, stigmastanol, stigmasterol, decurrenal, stigmasterol 3-O-β-D-glucopyranoside, and 5,10(15)-cadinen-4-ol. The structures of the new constituents have been established as (2E,11E)-12(benzo[1,3]dioxol-5-yl)-N-(2-methylpropyl)dodeca-2,11-dienamide (1), (2E,12Z)-N-(4-methylpentyl)octadeca-2,12-dienamide (2), and (2E,4S)-4-hydroxy-N-(2-methylpropyl)hex-2-enamide (3). The structures of 1-3 were derived by spectral studies and chemical reactions, and by comparison of spectral data in the case of known constituents. Compounds 1 and 2, and most of the already known compounds, exhibited toxicity against fourth instar larvae of Aedes aegypti Liston. The isolated (Z) double bond in 2 was assigned on the basis of its EI-MS fragmentation pattern and its reaction with OsO4. The (S) configuration at C(4) of 3 was determined by Horeau's method. This is the first report of the isolation of a 4-methylpentylamide from P nigrum, while shorter branched amides have been reported from this genus [1].

Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds

A method for the remote regioselective alkynylation of unactivated C(sp3)-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Photoredox-Catalyzed Site-Selective α-C(sp3)?H Alkylation of Primary Amine Derivatives

The synthetic utility of tertiary amines to oxidatively generate α-amino radicals is well established, however, primary amines remain challenging because of competitive side reactions. This report describes the site-selective α-functionalization of primary amine derivatives through the generation of α-amino radical intermediates. Employing visible-light photoredox catalysis, primary sulfonamides are coupled with electron-deficient alkenes to efficiently and mildly construct C?C bonds. Interestingly, a divergence between intermolecular hydrogen-atom transfer (HAT) catalysis and intramolecular [1,5] HAT was observed through precise manipulation of the protecting group. This dichotomy was leveraged to achieve excellent α/δ site-selectivity.

2-substituted parazoleamino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof

The invention relates to a series of new compounds as a JAK inhibitor, as well as compositions and applications thereof, and particularly provides a series of compounds (I) that have a strong JAK inhibiting activity, or stereisomers, geometrical isomers, tautomers, pharmaceutically acceptable salts, prodrugs, metabolites, isotope derivatives, and solvates, as well as medicine compositions comprising such compounds. The invention also discloses applications of the compounds or the medicine compositions in preparation of a medicine, which is used for treatment of autoimmune diseases or cancer.

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

α-Chiral amines are key intermediates for the synthesis of a plethora of chemical compounds at industrial scale. We present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows for the efficient and environmentally benign production of enantiopure amines. The method relies on a combination of two enzymes: an alcohol dehydrogenase (from Aromatoleum sp., Lactobacillus sp., or Bacillus sp.) operating in tandem with an amine dehydrogenase (engineered from Bacillus sp.) to aminate a structurally diverse range of aromatic and aliphatic alcohols, yielding up to 96% conversion and 99% enantiomeric excess. Primary alcohols were aminated with high conversion (up to 99%). This redox self-sufficient cascade possesses high atom efficiency, sourcing nitrogen from ammonium and generating water as the sole by-product.

Bicyclization of aza-compounds by positive halide ions. II. Lactams and some related cyclizations

Anodic oxidation of lactams in the presence of halide ions produced excellent yields of bicyclic compounds with reactants having rings in the range of eight to ten atoms (C7 to C9).Smaller rings did not react to form bicyclic products and larger rings gave reduced yields.Attempts were made to cyclize non-cyclic amides and to bicyclize cycloheptyl and cyclooctyl acetamide with limited success.