1119-29-5

Basic information

• Product Name: 4-MethylpentanaMide
• Synonyms: 4-MethylpentanaMide
• CAS NO: 1119-29-5
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 1119-29-5.mol

Chemical Properties

• Boiling Point: 245.2°C at 760 mmHg
• Flash Point: 102.1°C
• Appearance: /
• Density: 0.894g/cm³
• Vapor Pressure: 0.0291mmHg at 25°C
• Refractive Index: 1.431
• CAS DataBase Reference: 4-MethylpentanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MethylpentanaMide(1119-29-5)
• EPA Substance Registry System: 4-MethylpentanaMide(1119-29-5)

Safety Data

• Hazardous Substances Data: 1119-29-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Manufacturing:
4-Methylpentanamide is used as a precursor in the synthesis of certain pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Organic Synthesis:
As a versatile chemical intermediate, 4-Methylpentanamide is utilized in organic synthesis to produce a variety of other chemicals, expanding its applications across different industries.
Used as a Solvent:
4-Methylpentanamide serves as a solvent in various chemical processes, facilitating reactions and improving the efficiency of certain industrial applications.
Used as a Reagent in Chemical Reactions:
In addition to its role as a solvent, 4-Methylpentanamide is also employed as a reagent in chemical reactions, enabling specific transformations and contributing to the advancement of chemical research and development.
Used in Chemical Research and Development:
4-Methylpentanamide's properties make it a valuable tool in the field of chemical research and development, where it can be used to explore new reactions, syntheses, and applications.

InChI:InChI=1/C6H13NO/c1-5(2)3-4-6(7)8/h5H,3-4H2,1-2H3,(H2,7,8)

Upstream product

• 542-54-1 isocapronitrile 
• 38136-29-7 4-methylvaleroyl chloride 
• 108-10-1 4-methyl-2-pentanone 
• 646-07-1 4-Methylpentanoic acid 
• 127099-85-8 N-Cyanoguanidine 
• 74415-47-7 acetyl-(4-methyl-valeryl)-amine 
• 75-30-9 2-iodo-propane 
• 79-06-1 2-propenamide 
• 5977-14-0 acetoacetamido 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 5344-20-7 4-methyl pentanamine 
• 646-07-1 4-Methylpentanoic acid 
• 625-28-5 Isovaleronitrile 
• 204455-18-5 leucine p-toluenesulfonic acid 

Relevant articles and documents

Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds

A method for the remote regioselective alkynylation of unactivated C(sp3)-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.

Remote Regioselective Radical C-H Functionalization of Unactivated C-H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

The site-selective functionalization of unactivated aliphatic amines is an attractive and challenging synthetic approach. We herein report a general strategy for the remote site-selective functionalization of unactivated C(sp3)-H bonds in amides by photogenerated amidyl radicals to form gem-difluoroalkenes with trifluoromethyl-substituted alkenes. The site selectivity is controlled by a 1,5-hydrogen atom transfer (HAT) process of the amide. This photocatalyzed transformation shows both chemo- and site-selectivity, facilitating the formation of a secondary, tertiary, or quaternary carbon center.

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Directed γ-C(sp3)-H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis

Visible light photoredox catalysis enables direct γ- C(sp3)-H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ.

A method for preparing DL-leucine (by machine translation)

The invention discloses a method for preparing DL-leucine. The method of the invention first through ethanol, acetamide, ethanol sodium and isobutyl bromide reaction, reaction solution distillation recovery ethanol, distillation residues hot-melt, filtering, cooling to crystallize, shall be 2-isobutyl-acetamide; and then the 2-isobutyl-acetamide react with sodium hypochlorite, reaction solution distillation recovery chcl, distillation residual the toluene-P-sulfonic acid reaction, the reaction liquid filtering, cooling to crystallize, shall be leucine paratoluene sulfonic acid; leucines toluene-P-sulfonic acid with sodium hydroxide reaction, and the re-adjustment to pH 6-6.5 DL-leucine can be obtained. The invention chemical synthetic mild reaction conditions, the low requirements for the equipment, production cycle is short, with little investment, low cost; relatively high yield, there are few by-products, can be produced in large quantities, which is beneficial for industrial; acetamide can be formed by preparing ketene dimer, easily available raw materials. (by machine translation)

Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases

An isovaleramide analog having at least one of an increased potency, an increased half-life, and an increased stability compared to isovaleramide. The isovaleramide analog is a cyclic analog or a noncyclic analog. The isovaleramide analog is formulated into a pharmaceutical composition. A method of treating a central nervous system condition or disease is also disclosed. The method comprises administering an isovaleramide analog to a patient suffering from the central nervous system condition or disease.

Ultrasound in organic syntheses. 19. Further studies on the conjugate additions to electron deficient olefins in aqeuous media

Alkyl halides add smoothly to a variety of olefinic bonds conjugated with electron withdrawing groups, in the presence of zinc-copper couple. Sonication enhances the efficiency of the process, which takes place in aqeuous media following, most probably, a radical pathway.

COMPETITIVE TYPE II ELIMINATIONS IN ALIPHATIC IMIDES

Aliphatic imides have been shown to undergo type II eliminations across the imide moiety in addition to those on the C-alkyl chain and α cleavage reactions.