5350-68-5

Usage

InChI:InChI=1/C11H10O2/c1-7(12)10-6-8-4-2-3-5-9(8)11(10)13/h2-5,10H,6H2,1H3

Upstream product

• 83-33-0 inden-1-one 
• 75-36-5 acetyl chloride 
• 67-64-1 acetone 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 141-78-6 ethyl acetate 
• 50-00-0 formaldehyd 
• 93-91-4 1-phenylbutan-1,3-dione 
• 38870-89-2 Methoxyacetyl chloride 
• 645-45-4 hydrocinnamic acid chloride 
• 501-52-0 3-Phenylpropionic acid 
• 64-19-7 acetic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 6091-64-1 2-bromobenzoic acid ethyl ester 

Downstream Products

• 66234-15-9 10a,11-Dihydro-10a-hydroxy-benzoindeno<1.2-e><1.4>thiazin 
• 120-75-2 2-Methylbenzothiazole 
• 124530-80-9 N-acetyl-2-(2-aminophenylthio)indan-1-one 
• 83-33-0 inden-1-one 
• 1002345-70-1 (E)-5-(1-oxoindan-2-ylidene)-1-phenyl-3-(phenylamino)-2,5-dihydropyrrol-2-one 
• 1055177-33-7 (R)-2-acetyl-2-hydroxy-2,3-dihydro-1H-inden-1-one 
• 1353219-93-8 C₁₈H₁₅IO₂ 
• 904660-46-4 C₁₈H₁₆O₂ 
• 1353219-92-7 C₁₈H₁₅BrO₂ 

Relevant academic research and scientific papers

METHOD FOR PREPARING 1,3-DICARBONYL COMPOUND BASED ON METAL HYDRIDE/PALLADIUM COMPOUND SYSTEM

Disclosed is a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method includes the following steps: suspending a palladium compound and a metal hydride in a solvent under the protection of nitrogen, t

APPLICATION OF METAL HYDRIDE/PALLADIUM COMPOUND SYSTEM IN PREPARATION OF 1,3-DICARBONYL COMPOUND IN CASCADE REACTION OF ELECTRON-DEFICIENT ALKENE COMPOUND

Provided is an application of a metal hydride/palladium compound system in the preparation of a 1,3-dicarbonyl compound in a cascade reaction of an electron-deficient alkene compound, said reaction comprising the following steps: under the protection of n

Enantioenriched Quaternary α-Pentafluoroethyl Derivatives of Alkyl 1-Indanone-2-Carboxylates

An electrophilic enantioselective catalytic method for the α-pentafluoroethylation of 3-oxoesters is described. Under the use of La(OTf)3 in combination with a (S,R)-indanyl-pybox ligand, good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions, leading to the formation of enantioenriched quaternary centers. This methodology uses an hypervalent iodine(III)-CF2CF3 reagent, and mechanistic investigations are consistent with the involvement of a radical pathway.

Pyrazoles: 'one-pot' synthesis from arenes and carboxylic acids

A rapid and efficient method for 'one-pot' synthesis of pyrazoles from (hetero)arenes and carboxylic acids via successive formation of ketones and β-diketones followed by heterocyclization with hydrazine has been developed. The utility of the RCOOH/TfOH/TFAA acylation system for intermediate production of ketones and 1,3-diketones is a key feature of this approach. The preliminary evaluation of the anticancer activity of the synthesized pyrazoles is performed.

Redetermination of the Structure of a Water-Soluble Hypervalent Iodine(V) Reagent AIBX and Its Synthetic Utility in the Oxidation of Alcohols and Synthesis of Isoxazoline N-Oxides

The structure of a water-soluble hypervalent iodine(V) reagent AIBX is re-examined through its single-crystal X-ray analysis and theoretical calculations including Mayer bond order and localized orbital locator (LOL) and AIBX is believed to be a pseudocyclic iodylarene because of the strong electron-withdrawing nature of the trimethylammonium cation on its phenyl ring, which would decrease the electron density of carboxylic anion and make the ortho-carboxyl oxygen anion incapable to form hypervalent bond with iodine atom. However, the cyclic benziodoxole structure of AIBX could be obtained by adding a Br?nsted acid, which was supported by the calculation result including the increase of Mayer bond order and the shortening of the I-O bond length. Moreover, the fact that the system of AIBX and TFA could oxidize various alcohols to their corresponding carbonyl compounds would indicate that AIBX constitutes a cyclic benziodoxole structure under acidic conditions. In addition, an efficient method has been developed for the synthesis of isoxazoline N-oxides via AIBX-induced dehydrogenative cyclization using β-keto esters as substrates and methyl nitroacetate as a nucleophile.

The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of α, β-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules. (Figure presented.).

Method for preparing 1,3-dicarbonyl compound based on metal hydride/palladium compound system

The invention discloses a method for preparing a 1,3-dicarbonyl compound based on a metal hydride/palladium compound system. The method comprises the following steps: making a palladium compound and metal hydride suspend in a solvent under the protection

Application of metal hydride/ palladium compound system in preparing 1,3-dicarbonyl compound through cascade reaction in electron-deficient alkene compound

The invention discloses application of a metal hydride/ palladium compound system in preparing a 1,3-dicarbonyl compound through cascade reaction in an electron-deficient alkene compound. The reactioncomprises the following steps of under the protection o

Recyclable Hypervalent-Iodine-Mediated Dehydrogenative α,β′-Bifunctionalization of β-Keto Esters under Metal-Free Conditions

We have developed a method for recyclable hypervalent-iodine-mediated direct dehydrogenative α,β′- bifunctionalization of β-ketoesters and β-diketones under metal-free conditions, which affords a straightforward way to synthesize benzo-fused 2,3-dihydrofurans. This efficient, mild method, which has a wide substrate scope and good functional-group tolerance, was used for the multistep synthesis of the protected aglycone of a naturally occurring phenolic glycoside. A mechanism involving Michael addition to an enone intermediate and subsequent oxidative cyclization is proposed.

Synthesis of indanones by sequential Heck-reduction-cyclization-alkylation (HRCA) reactions

A simple and efficient synthesis of indanones, bearing a quaternary carbon centre, has been developed. The method features, in a one-pot process, the use of a multi-task palladium catalyst for the sequential Heck-reduction reactions, followed by a base-me