53668-52-3

Upstream product

• 157560-07-1 (E)-methyl 4-nitro-7-phenyl-4-heptenoate 
• 108-30-5 succinic acid anhydride 
• 1462-75-5 3-phenylpropylmagnesium bromide 
• 92423-60-4 7-phenyl-heptane-1,4-diol 
• 16520-62-0 4-Phenyl-1-butyne 
• 140-88-5 ethyl acrylate 
• 292638-85-8 acrylic acid methyl ester 
• 937-41-7 phenyl acrylate 
• 1663-39-4 tert-Butyl acrylate 
• 104-53-0 3-phenyl-propionaldehyde 
• 170943-53-0 (E)-4-Amino-4-(3-phenyl-propyl)-pent-2-enedioic acid diethyl ester 
• 857609-28-0 3-oxo-2-phenethyl-adipic acid dimethyl ester 
• 108972-13-0 ethyl 4-oxo-7-phenylheptanoate 

Downstream Products

• 675589-41-0 (3R,7aS)-3-phenyl-7a-(3-phenylpropyl)-2,3,7,7a-tetrahydropyrrolo[2,1-b]oxazol-5-one 
• 138298-35-8 (S)-5-((E)-3-Phenyl-allyl)-dihydro-furan-2-one 
• 138298-35-8 (R)-5-((E)-3-Phenyl-allyl)-dihydro-furan-2-one 
• 138298-41-6 Acetic acid 4-hydroxy-7-phenyl-heptyl ester 
• 138298-47-2 Acetic acid 4-phenyl-1-propyl-butyl ester 
• 144741-88-8 1-phenylheptan-4-ol 
• 40228-90-8 7-phenylheptanoic acid 

Relevant academic research and scientific papers

Ruthenium-catalyzed three-component coupling via hydrative conjugate addition of alkynes to alkenes: One-pot synthesis of 1,4-dicarbonyl compounds

A catalytic three-way rendezvous: Terminal alkynes undergo metal vinylidene formation, anti-Markovnikov hydration to give a metal acyl complex, and conjugate addition to produce synthetically useful 1,4-dicarbonyl compounds under ruthenium catalysis. This one-pot three-component coupling reaction is a useful platform for further exploration in alkyne functionalization.

Asymmetric synthesis of spiro 2-pyrrolidin-5-ones, 2-piperidin-6-ones and 1-isoindolin-3-ones. Part 1: N-acyliminium ion cyclisations with an internal arene nucleophile

A series of chiral non-racemic 5,5- and 5,6-bicyclic lactams is prepared from (R)-phenylglycinol. These are isomerised on treatment with aluminium trichloride in 1,2-dichloroethane to give spiro lactams in high yield and >3:1 diastereoselectivity. From four structures determined by X-ray crystallography, it follows that spiro indenes are formed preferentially with retention of configuration at the spiro carbon atom and spiro naphthalenes with inversion.

First Michael addition reaction of α-substituted N-diphenylmethyleneglycinate with ethyl propiolate. Synthesis of α-substituted (E)-3,4-dehydroglutamic acids

(E)-α-substituted 3,4-dehydro glutamic acids 4, were prepared from ethyl N-diphenylmethyleneglycinate 5 by alkylation with a suitable alkyl halide followed by a Michael type addition reaction with ethyl propiolate, giving rise to a mixture of E/Z adducts 7/8. Sequential hydrolysis of the substituted glycine synthons 7/8 afforded the titled compounds 4 as single diastereomers.

Chemoselective conversion of conjugated nitroalkenes into ketones by sodium borohydride-hydrogen peroxide: A new synthesis of 4-oxoalkanoic acids, dihydrojasmone and (±)exo-brevicomin

A new, simple, cheap, and practical procedure for the direct transformation of α,β-unsaturated nitroalkenes into ketones has been realized by the NaBH4/H2O2 system. By this method, other functional groups such as C-C double bonds, ketals or aromatic nitro groups were preserved. Application of this methodology to the preparation of 4-oxoalkanoic acids, dihydrojasmone, and (±)-exobrevicomin is also reported.

Novel prolinal derivatives

A novel prolinal derivative of general formula: STR1 wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms, n represents a number 2, 3 or 4, D represents carbocyclic or heterocyclic rin