5392-86-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichlorophenetole is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-dichlorophenetole is employed as an intermediate in the production of agrochemicals, aiding in the creation of substances that protect crops and enhance agricultural productivity.
Used as a Solvent in Chemical Reactions:
2,4-Dichlorophenetole is utilized as a solvent in a range of chemical processes, facilitating reactions and improving the efficiency of chemical synthesis.

InChI:InChI=1/C8H8Cl2O/c1-2-11-8-4-3-6(9)5-7(8)10/h3-5H,2H2,1H3

Upstream product

• 75-03-6 ethyl iodide 
• 120-83-2 2,4-dichlorophenol 
• 103-73-1 Phenetole 
• 622-61-7 1-chloro-4-ethoxybenzene 
• 109-63-7 boron trifluoride diethyl etherate 
• 64-17-5 ethanol 
• 1435-48-9 1,3-dichloro-4-fluorobenzene 
• 120-36-5 2-(2,4-dichlorophenoxy)propionic acid 

Downstream Products

• 122756-30-3 2,4-dichloro-6-nitro-phenetole 
• 120-83-2 2,4-dichlorophenol 

Relevant academic research and scientific papers

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes

C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron-poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chemistry which generally requires basic reaction conditions and high temperatures, and provides products under non-basic conditions at ≈ 40 °C.

A new alkylation of aryl alcohols by boron trifluoride etherate

The ethylation of aryl alcohols by an ethyl moiety of boron trifluoride etherate is described. The reaction proceeded cleanly and afforded good yields of the corresponding aryl ethyl ethers. It tolerated the presence of functional groups such as aryl, alkyl, halogens, nitro, nitrile, and amino. However, the presence of amino or nitro groups ortho to a hydroxyl group of an aryl compound drastically reduced the yields of the anticipated products due to the chelation of the aforementioned functional groups with boron trifluoride etherate. A nitrogen atom in the aromatic ring system, as exemplified by hydroxypyridine and 8-hydroxyquinoline, completely inhibited the reaction. Resorcinol, hydroquinone, and aryl alcohols with aldehyde functions decomposed under the reaction conditions.

Formation of Nonaromatic Products in the Chlorination of Simple Substituted Aromatic Ethers

The neat chlorination of 4-chloroanisole produces 1,3,4,5,6-pentachloro-4-methoxycyclohexene in 35percent yield.Mono- and dichlorinated anisoles and a variety of simple substituted anisoles were chlorinated to determine the generality of nonaromatic product formation. 3,4-Dichloroanisole, 4-fluoroanisole, 4-bromoanisole, 4-methylanisole, and 4-chlorophenetole form similar products based on their spectral properties.These products are proposed to form by a cis-1,2-chlorine addition followed by rapid cis-1,4 chlorine addition.On the basis of the NMR data, a predominate configuration is proposed.