53924-36-0

Upstream product

• 120-72-9 indole 
• 100-52-7 benzaldehyde 
• 121-69-7 N,N-dimethyl-aniline 
• 35173-74-1 3,3'-bis-indolyl(phenyl)methane 
• 1561041-27-7 C₁₈H₁₉NO 
• 51626-58-5 (1H-indol-3-yl)(phenyl)methanol 
• 59836-46-3 1-(1H-indol-3-yl)-N,N-dimethyl-1-phenylmethanamine 

Relevant academic research and scientific papers

A revisit to the multi-component reaction of indole, aldehyde, and N-substituted aniline catalyzed by PMA–SiO2

Abstract: PMA–SiO2-catalyzed multi-component reaction of indole, aromatic aldehyde, and N-substituted aniline at room temperature under solvent-free condition is reported here. The reaction was previously reported, where a C–C and C–N bond were

L-Proline catalyzed domino Michael addition of N-substituted anilines

Here we report L-proline catalyzed 3-component reaction of indoles, aldehydes and N-substituted anilines in water as solvent at room temperature for the synthesis of 3-(α,α-diarylmethyl)indoles. The reaction is in fact a Michael addition of N-substituted

Air-stable μ2-hydroxyl bridged cationic binuclear complexes of zirconocene perfluorooctanesulfonates: their structures, characterization and application

Three air-stable zirconocene perfluoro-octanesulfonates were successfully synthesized by treatment of C8F17SO3Ag with (RCp)2ZrCl2 [R = H, n-Bu, t-Bu]. According to X-ray analysis, they have μ2-hydroxyl bridged cationic binuclear structures: (i) [CpZr(OH2)3]2(μ2-OH)2(OSO2C8F17)4·2THF·4H2O (1a·2THF·4H2O), (ii) [n-BuCpZr(OH2)3]2(μ2-OH)2(OSO2C8F17)4·6H2O (2a·6H2O), and (iii) [t-BuCpZr(OH2)3]2(μ2-OH)2(OSO2C8F17)4·2C3H6O·8H2O (3a·2C3H6O·8H2O). The ligands of water and organic molecules in the complexes originated from the moist air and solvent during their recrystallization. These complexes were characterized with different techniques, and found to show water tolerance, air/thermal stability as well as strong Lewis acidity. Moreover, the complexes showed highly catalytic activity in various reactions of C–C bond formation. With good recyclability, they should find wide applications in organic chemistry.

One-pot sequential multi-component reaction: Synthesis of 3-substituted indoles

Here, we have developed a 3-component one-pot sequential approach to 3-substituted indoles. The main advantages of this process are step economy, reduced waste, and operational simplicity. The method involves in situ generation of 3-indolylalcohols from t

Three-component synthesis of 3-(diarylmethyl)indoles using Fe(ClO4)3/SiO2 as catalyst

Three-component reaction of indole, aromatic aldehyde, and N,N-dimethyl aniline in the presence of silica-supported Fe(ClO4)3 as catalyst afforded the corresponding 3-[aryl(4-dimethylaminophenyl)methyl]-indoles in excellent yields un

A regioselective one-pot aza-Friedel-Crafts reaction for primary, secondary and tertiary anilines using a heterogeneous catalyst

A one-pot multicomponent aza-Friedel-Crafts reaction was performed under green, neat and heterogeneous conditions in the presence of 1.25 mmol% of 30% w/w silicotungstic acid supported on Amberlyst 15 beads. In a yet unprecedented attempt, both primary an

Hydrogen-Bond-Catalyzed Arylation of 3-(Aminoalkyl)indoles via C-N Bond Cleavage with Thiourea under Microwave Irradiation: An Approach to 3-(α,α-Diarylmethyl)indoles

We have developed a simple and efficient method for the arylation of 3-(aminoalkyl)indoles with aryl alcohols and other aromatic nucleophiles through C-N bond cleavage under microwave irradiation to synthesize 3-(α,α-diarylmethyl)indoles. The method uses thiourea as catalyst, which is environmentally benign, water-tolerant and easy to handle. Notably, acid-sensitive substrates are tolerated under the reaction conditions. Thiourea activates the tertiary amine through double hydrogen bonding and converts it into a better leaving group. The reaction proceeds through the formation of vinylogous iminium ion as an intermediate.

Magnetically separable sulfonic acid catalysed one-pot synthesis of diverse indole derivatives

Fe3O4-OSO3H was identified as an efficient reusable catalyst for the facile synthesis of diarylmethyl indole derivatives under neat condition by C-C bond forming reaction. Fe3O4-OSO3H catal

PMA-SiO 2-Mediated MCR in PEG-400: A Greener aza-Friedel-Crafts Reaction Leading to 3-Arylmethyl/Diarylmethyl Indoles

A greener approach for the synthesis of 3-arylmethyl/diarylmethyl indoles has been achieved via a PMA-SiO2-mediated three-component reaction (the aza-Friedel-Crafts reaction) involving indoles, aldehydes, and N,N-disubstituted anilines in PEG-4