59836-46-3

Upstream product

• 108-86-1 bromobenzene 
• 120-72-9 indole 
• 52853-20-0 benzylidene dimethyl ammonium chloride 
• 100-52-7 benzaldehyde 
• 124-40-3 dimethyl amine 

Downstream Products

• 53924-36-0 4-((1H-indol-3-yl)(phenyl) methyl)-N,N-dimethylaniline 
• 1172117-12-2 3-(phenyl(2,4,6-trimethoxyphenyl)methyl)-1H-indole 
• 907179-29-7 3-[(1H-indol-3-yl)(phenyl)methyl]-2-methyl-1H-indole 
• 1092390-78-7 3-[(1H-indol-3-yl)(phenyl)methyl]-1-methyl-1H-indole 

Relevant academic research and scientific papers

Catalyst-free, solvent-promoted and scalable multicomponent synthesis of 3-aminoalkylated indoles via a mannich-type reaction

A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.

Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water

An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles has been developed via a three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. In this Mannich-type reaction

Subtituted indole mannich bases

The invention relates to substituted indole Mannich bases of formula (I), a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments, especially medicaments that are used to treat pain. In formula (I), R1,R2, R4-R7 have the meanings cited in claim 1, R3=formula (a) and R13=(substituted) phenyl.

Lithium perchlorate assisted one-pot three-component aminoalkylation of electron-rich aromatic compounds

A one-pot, three-component, Mannich reaction of electron-rich aromatic compounds with in situ prepared iminium salts in 5 M ethereal lithium perchlorate gives good yields of aminoalkylated products at room temperature.

Aminoalkylation of electron-rich aromatic compounds using preformed iminium salts derived from aldehydes other than formaldehyde

Preformed iminium salts derived from aldehydes other than formaldehyde are demonstrated to be excellent reagents for the aminoalkylation of indoles, phenols and N,N-dimethylaniline. This method provides a simple and straightforward route to a variety of aromatic Mannich bases which are difficult to obtain by other procedures. Surprisingly, the reaction between N-methylindole or 2-naphthol with a preformed N-silyl iminium salt led to the formation of a bisindolylmethane or a dihydrooxazine derivative, respectively.