53975-33-0

Basic information

• Product Name: Pyrimidine, 4-(4-bromophenyl)- (9CI)
• Synonyms: Pyrimidine, 4-(4-bromophenyl)- (9CI)
• CAS NO: 53975-33-0
• Molecular Formula: C₁₀H₇BrN₂
• Molecular Weight: 235.07998
• Product Categories: QUINAZOLINE;PYRIMIDINE
• Mol File: 53975-33-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 4-(4-bromophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-(4-bromophenyl)- (9CI)(53975-33-0)
• EPA Substance Registry System: Pyrimidine, 4-(4-bromophenyl)- (9CI)(53975-33-0)

Safety Data

• Hazardous Substances Data: 53975-33-0(Hazardous Substances Data)

Upstream product

• 5467-74-3 4-Bromophenylboronic acid 
• 31462-56-3 4-brornopyrirnidine 
• 59862-55-4 p-bromoacetophenone oxime 
• 299456-72-7 1-(4-bromophenyl)ethanone O-acetyl oxime 
• 149-73-5 trimethyl orthoformate 
• 99-90-1 para-bromoacetophenone 
• 3473-63-0 formamidine acetic acid 
• 73387-60-7 1-(4-bromophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 290-87-9 1,3,5-Triazine 
• 98-86-2 acetophenone 
• 122-51-0 orthoformic acid triethyl ester 
• 6966-73-0 triformylaminomethane 
• 77287-34-4 formamide 

Downstream Products

• 1566622-88-5 C₂₂H₁₅BrN₂O₃ 
• 883822-83-1 C₂₄H₁₉BrN₂O₄ 
• 1566622-93-2 C₂₂H₁₄BrClN₂O₂ 
• 1566622-97-6 C₂₂H₁₄BrClN₂O₃ 
• 302912-76-1 C₂₃H₁₆BrClN₂O₃ 
• 302912-78-3 C₂₃H₁₆Br₂N₂O₃ 
• 1566623-02-6 C₂₂H₁₄BrN₃O₅ 
• 1450897-59-2 4-(4-(methylthio)phenyl)pyrimidine 
• 16495-82-2 4-(4-nitrophenyl)pyrimidine 
• 145654-70-2 4-(4-(1-n-propyl-2-1H-pyrryl)phenyl)pyrimidine 
• 181133-22-2 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(4-pyrimidinyl)[1,1'-biphenyl]-2-sulfonamide 
• 145654-85-9 4-(4-bromophenyl)-6-n-butyl-pyrimidine 
• 145654-63-3 3-(1,3-dioxolan-2-yl)-1-(4-(2-pyrimidyl)phenyl)-1-propanone 

Relevant articles and documents

Asymmetric pyrene derivatives comprising aryl amine group and organic light-emitting diode including the same

The present invention relates to asymmetric pyrene derivatives represented by chemical formula A or chemical formula B and to an organic light-emitting device including the same, wherein substituents of Ar1, Ar2, Ar3, Ar4, Z and m are as defined in the detailed description of the present invention.

Oxidative Annulations Involving DMSO and Formamide: K2S2O8 Mediated Syntheses of Quinolines and Pyrimidines

An efficient strategy toward 4-arylquinolines and 4-arylpyrimidines from readily available precursors is described. Oxidative annulation promoted by K2S2O8 involving anilines, aryl ketones, and DMSO as a methine (=CH-) equivalent leads to 4-arylquinolines via a cascade that entails generation of a sulfenium ion, subsequent C-N and C-C bond formations, and cyclization. The application of this strategy to the activation of acetophenone-formamide conjugates toward the synthesis of 4-arylpyrimidines is also described.

Synthesis, activity and docking studies of phenylpyrimidine–carboxamide Sorafenib derivatives

Two series of Sorafenib derivatives bearing phenylpyrimidine–carboxamide moiety (16a–g and 17a–p) were designed, synthesized and evaluated for the IC50values against three cancer cell lines (A549, MCF-7 and PC-3). Two selected compounds (17f and 17n) were further evaluated for the activity against VEGFR2/KDR kinase. More than half of the synthesized compounds showed moderate to excellent activity against three cancer cell lines. Compound 17f showed equal activity to Sorafenib against MCF-7 cell line, with the IC50values of 6.35 ± 0.43 μM. Meanwhile, compound 17n revealed more active than Sorafenib against A549 cell line, with the IC50values of 3.39 ± 0.37 μM. Structure–activity relationships (SARs) and docking studies indicated that the second series (17a–p) showed more active than the first series (16a–g). What's more, the introduction of fluoro atom to the phenoxy part played no significant impact on activity. In addition, the presence of electron-donating on aryl group was benefit for the activity.