54001-23-9Relevant academic research and scientific papers
Synthesis and antibacterial activities of pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety
Wang, Liang,Dai, Fu-Ying,Zhu, Jie,Dong, Kui-Kui,Wang, Yu-Liang,Chen, Tian
experimental part, p. 313 - 316 (2011/10/05)
Seven novel pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety in the C14 side chain were designed and synthesised. The antibacterial activities of the target compounds were tested via agar-well diffusion method in vitro. The results showed that three target compounds still had antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC at a low concentration of 0.05 μg mL-1.
