10058-38-5

Usage

Uses

Used in Organic Synthesis:
2-Phenyl-thiazole-5-carboxylic acid is used as a versatile building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its chemical reactivity allows for the formation of a wide range of compounds with potential applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Phenyl-thiazole-5-carboxylic acid is utilized as a key component in the development of new drugs. Its presence in bioactive molecules contributes to the discovery of novel therapeutic agents with potential applications in treating various diseases and conditions.
Used in Drug Discovery:
2-Phenyl-thiazole-5-carboxylic acid is employed as a valuable target in drug discovery, where its unique structure and properties are harnessed to identify and develop new pharmaceutical compounds with improved efficacy and safety profiles.
Used in Material Science:
In material science, 2-Phenyl-thiazole-5-carboxylic acid is used for the development of innovative materials with specific properties. Its chemical versatility allows for the creation of materials with potential applications in various fields, such as electronics, coatings, and advanced materials for specialized industries.

InChI:InChI=1/C10H7NO2S/c12-10(13)8-6-11-9(14-8)7-4-2-1-3-5-7/h1-6H,(H,12,13)

Upstream product

• 172678-67-0 ethyl 2-phenyl-1,3-thiazole-5-carboxylate 
• 1011-40-1 2-phenyl-1,3-thiazole-5-carbaldehyde 
• 2227-79-4 benzenecarbothioamide 
• 23665-09-0 phenylzinc iodide 
• 54045-74-8 methyl 2-bromo-1,3-thiazole-5-carboxylate 
• 98-80-6 phenylboronic acid 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 55-21-0 benzamide 

Downstream Products

• 54001-23-9 2-phenyl-thiazole-5-carbonyl chloride 
• 90842-20-9 2-phenyl-thiazole-5-carboxylic acid amide 
• 859481-55-3 2-(4-nitro-phenyl)-thiazole-5-carbonyl chloride 
• 651326-31-7 2-chloro-1-[2-(4-nitro-phenyl)-thiazol-5-yl]-ethanone 
• 860372-85-6 2-diazo-1-[2-(4-nitro-phenyl)-thiazol-5-yl]-ethanone 
• 854455-19-9 2'-(4-nitro-phenyl)-[4,5']bithiazolyl 
• 50680-67-6 N-β-[4'-(o-methoxyphenyl)-1'-piperazinyl]-ethyl-2-phenylthiazol-5-carboxamide 
• 1332459-55-8 C₃₆H₄₈N₂O₅S₂ 
• 1442120-48-0 4-methyl-2-({1-[(2-phenylthiazol-5-yl)carbonyl]piperidin-4-yl}methyl)-N-(2,2,2-trifluoroethyl)-2H-indazole-5-carboxamide 
• 351428-32-5 N-methoxy-N-methyl-2-phenylthiazole-5-carboxamide 
• 10045-50-8 1-(2-phenylthiazol-5-yl)ethan-1-one 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

A compound of formula (I), wherein Ar1, R21, R23, R24, R25, R26, R27, A, X, Y and W are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. Here, w

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

Synthesis and antibacterial activities of pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety

Seven novel pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety in the C14 side chain were designed and synthesised. The antibacterial activities of the target compounds were tested via agar-well diffusion method in vitro. The results showed that three target compounds still had antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC at a low concentration of 0.05 μg mL-1.

Erythromycin derivatives

A compound selected from the group consisting of a compound of the formula STR1 wherein R1 and R2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form STR2 and R'1 and R'2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.