5402-53-9

Usage

Uses

Used in Pharmaceutical Industry:
Chloromethyl propanoate is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Industry:
It is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Fragrance Industry:
Chloromethyl propanoate is used as a key component in the synthesis of esters, which are essential in creating a wide range of fragrances for various applications.
Used in Flavor Industry:
chloromethyl propanoate contributes to the creation of diverse flavors in the food and beverage industry by being part of the ester synthesis process.
Used in Cosmetics Industry:
Chloromethyl propanoate plays a role in the formulation of cosmetics, where esters derived from it enhance the scent and other properties of cosmetic products.
Note: It is important to handle chloromethyl propanoate with care due to its hazardous nature, as it can cause irritation to the skin, eyes, and respiratory system if proper safety measures are not followed.

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 50-00-0 formaldehyd 
• 79-03-8 propionyl chloride 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 74-97-5 chlorobromomethane 
• 327-62-8 potassium propionate 
• 49715-04-0 chlorosulfuric acid chloromethyl ester 
• 802294-64-0 propionic acid 

Downstream Products

• 47656-35-9 6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid propionyloxymethyl ester 
• 116548-36-8 Propionic acid 2-benzoylamino-acetoxymethyl ester 
• 138279-15-9 bis(propionyloxymethyl) 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 138548-29-5 1,3-bis(propionyloxymethyl)-5-methyl-5-phenylbarbital 
• 27506-81-6 1,3-bis(propionyloxymethyl)-5-ethyl-5-phenylbarbital 
• 138548-32-0 5-(1-cyclohexenyl)-1,3-bis(propionyloxymethyl)-5-ethylbarbital 
• 138548-30-8 1,3-bis(propionyloxymethyl)-5-phenyl-5-propylbarbital 
• 167221-70-7 Propionoxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1242097-40-0 (Z)-5-phenyl-2-propylpent-2-enyl propionate 
• 1242097-42-2 (Z)-4-methyl-2-(3-phenoxypropyl)hept-2-enyl propionate 
• 1280193-67-0 (Z)-5-phenylpent-2-en-1-yl propionate 

Relevant academic research and scientific papers

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

PESTICIDALLY ACTIVE AZETIDINE SULFONES AMIDE ISOXAZOLINE DERIVATIVES

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C-H Bonds with NaCl/Oxone at Room Temperature

A visible light-induced monochlorination of cyclohexane with sodium chloride (5:1) has been successfully accomplished to afford chlorocyclohexane in excellent yield by using Oxone as the oxidant in H2O/CF3CH2OH at room temperature. Other secondary and primary alkyl sp3 C-H bonds of cycloalkanes and functional branch/linear alkanes can also be chlorinated, respectively, under similar conditions. The selection of a suitable organic solvent is crucial in these efficient radical chlorinations of alkanes in two-phase solutions. It is studied further by the achievement of high chemoselectivity in the chlorination of the benzyl sp3 C-H bond or the aryl sp2 C-H bond of toluene.

Substituted aza indole compounds and salts thereof, composition and use thereof

The invention provides a substituted azaindole compound having a structure as represented by a formula (I) and a pharmaceutically acceptable salt and a medicinal preparation thereof. The compound is used for adjusting activity of protein kinase and adjusting intercellular or intracellular signal response. The invention further relates to a pharmaceutical composition including the compound and a method of applying the pharmaceutical composition to treatment of highly proliferative diseases of mammals, especially of mankind.

SUBSTITUTED AZAINDOLE COMPOUNDS, SALTS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS OF USE

The present invention provides substituted azaindole prodrugs, methods of making said prodrugs, pharmaceutical compositions of said prodrugs and methods of using said prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer.

PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF

The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.

Synthesis of acyloxyalkyl esters of thiocarbonic and dithiocarbamic acids

Reactions of acyloxyalkyl chloride with alkaline salts of alkylxanthic, butyltrithiocarbonic, and diethyldithiocarbamic acids afforded a series of acyloxyalkyl esters of various nature and positions of the acyl groups in the molecule.

Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA

Purpose: Biolabile cationic lipids were developed for efficient intracellular delivery of DNA and siRNA. Methods: The compounds have been designed starting from the membrane lipid DOPC in a way they may loose their cationic charge when exposed to an acidic and/or enzymatic stimulus, such as those met during the journey of a lipoplex in biological media. Results: They demonstrated remarkable efficiency to deliver DNA in various cell lines (BHK-21, Calu-3, NCI-H292, and A549), with no significant cytotoxicity. Furthermore, two of the compounds (carbonate-based DOPC derivatives) revealed able to deliver small interfering RNA in U87Luc and A549Luc cancer cells and to mediate a selective 70-80% knockdown of the stably transfected luciferase gene. Conclusions: The results show that the described bioresponsive cationic lipids have high DNA and siARN delivery activity which is encouraging in view of delivering a therapeutic nucleic acid to pulmonary tissues in vivo.