Radiation-induced Alkylation, Hydroxyalkylation, and Reduction of Pyridinecarboxamides in Acidic Alcoholic Solutions

Article abstract of DOI:10.1246/bcsj.55.3055

The γ-irradiation of pyridinecarboxamides in acidic methanol or ethanol brings about substitution of the ring hydrogen by alkyl or hydroxyalkyl groups derived from the solvent alcohols in relatively high G-values.In 2-propanol, little alkylation and hydroxyalkylation occur and reduction of CONH2 to CH2OH occurs in low G-values.