54095-29-3

Upstream product

• 3172-52-9 2,5-diclorothiophene 
• 100-66-3 methoxybenzene 
• 82437-75-0 3-(4-methoxy-phenyl)-thiophene 

Downstream Products

• 82437-75-0 3-(4-methoxy-phenyl)-thiophene 
• 134640-54-3 4,4'-bis(p-methoxyphenyl)-2,2'-bithienyl 
• 134640-44-1 5-chloro-3,4'-bis(p-methoxyphenyl)-2,2'-bithienyl 
• 92-52-4 biphenyl 
• 108979-04-0 4-(p-methoxyphenyl)-2-phenylthiophene 
• 158837-31-1 5-chloro-2-iodo-3-(p-methoxyphenyl)thiophene 
• 158837-41-3 2-chloro-4-(p-methoxyphenyl)-5-phenylthiophene 
• 134640-49-6 3,4'-bis(p-methoxyphenyl)-2,2'-bithienyl 

Relevant academic research and scientific papers

Synthesis of unsymmetrical 2,3-diaryl- and 2,4-diarylthiophenes starting from 2,5-dichlorothiophene

Unsymmetrically substituted 2,4-diaryl- and 2,3-diarylthiophenes were synthesized from 2,5-dichlorothiophene via 4-aryl-2-chlorothiophenes in two and four steps including Ni-mediated cross-coupling, respectively. Aluminum chloride-catalyzed reaction of 3-aryl-2-chlorothiophenes with some aromatic ethers unexpectedly led to the formation of the corresponding 2,4-isomers.

A New and Simple Route to 3-Arylthiophenes

3-Arylthiophenes were prepared from 2,5-dichlorothiophene in two steps. 2,5-Dichlorothiophene reacted regioselective with various aromatic compounds in the presence of AlCl3 under mild conditions to give 4-aryl-2-chlorothiophenes.The latter compounds were easily converted to the corresponding 3-arylthiophenes by catalytic dechloronation in good yields.