541-23-1

Usage

Uses

Used in Pharmaceutical Industry:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as a pharmaceutical intermediate for the production of various drugs. It plays a crucial role in the synthesis of medicinal compounds, contributing to the development of new pharmaceuticals.
Used in Organic Synthesis:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as a reactant in organic synthesis, enabling the creation of a wide range of organic compounds for various applications.
Used in Agrochemical Production:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as an intermediate in the manufacture of agrochemicals, contributing to the development of products that support agricultural processes and crop protection.
Used in Food Additive Industry:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as an intermediate in the production of food additives, playing a role in enhancing the quality, taste, or preservation of food products.
It is important to handle 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE with caution due to its corrosive nature, as it can cause irritation to the skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C5H13N.ClH/c1-5(2)3-4-6;/h5H,3-4,6H2,1-2H3;1H

Upstream product

• 627-67-8 1-nitro-3-methylbutane 
• 107-85-7 1-amino-3-methylbutane 
• 2695-37-6 sodium 4-styrenesulfonate 
• 51411-34-8 Benzhydrylidene-(3-methyl-butyl)-amine 
• 541-46-8 isobutylamide 
• 625-28-5 Isovaleronitrile 
• 590-86-3 isovaleraldehyde 
• 250650-58-9 N-diphenylmethyl-3-methyl-butylamine 

Downstream Products

• 147972-14-3 4'-[[[2-[(3-methylbutyl)amino]-4-quinazolinyl]amino]methyl][1,1'-biphenyl]-2-carboxylic acid methyl ester 
• 1583283-24-2 (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium 
• 1583283-69-5 C₂₁H₃₆N₃O₅P 
• 84851-37-6 (S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride 
• 84863-67-2 (S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate 
• 578-20-1 Egressin 

Relevant academic research and scientific papers

Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions

Hydrogenation of nitriles to primary amines with heterogeneous catalysts under liquid-phase continuous-flow conditions is described. Newly developed polysilane/SiO2-supported Pd was found to be an effective catalyst and various nitriles were converted into primary amine salts in almost quantitative yields under mild reaction conditions. Interestingly, a complex mixture was obtained under batch conditions. Lifetime experiments showed that this catalyst remained active for more than 300 h (TON≥10 000) without loss of selectivity and no metal leaching from the catalyst occurred. By using this continuous-flow hydrogenation, synthesis of venlafaxine, an antidepressant drug, has been accomplished.

Rapid Conventional and Microwave-Assisted Decarboxylation of L-Histidine and Other Amino Acids via Organocatalysis with R-Carvone under Superheated Conditions

This article reports a new methodology taking advantage of superheated chemistry via either microwave or conventional heating for the facile decarboxylation of alpha amino acids using the recoverable organocatalyst, R-carvone. The decarboxylation of amino acids is an important synthetic route to biologically active amines, and traditional methods of amino acid decarboxylation are time consuming (taking up to several days in the case of L-histidine), are narrow in scope, and make use of toxic catalysts. Decarboxylations of amino acids including L-histidine occur in just minutes while replacing toxic catalysts with green catalyst, spearmint oil. Yields are comparable to or exceed previous methods and purification of product ammonium chloride salts is aided by an isomerization reaction of residual catalyst to phenolic carvacrol. The method has been shown to be effective for the decarboxylations of a range of natural, synthetic, and protected amino acids.

Hydrogenation of Aliphatic and Aromatic Nitriles Using a Defined Ruthenium PNP Pincer Catalyst

Selective catalytic reductions of nitriles are presented using the commercially available Ru-Macho-BH complex. A variety of aliphatic, aromatic and (hetero)cyclic nitriles including industrially important adipodinitrile are hydrogenated to the corresponding primary amines. Modelling suggests the reaction follows an outer sphere hydrogenation mechanism. An efficient and selective catalytic reduction of nitriles is presented using the commercially available Ru-Macho-BH complex. A variety of aliphatic, aromatic and (hetero)cyclic nitriles including the industrially important adipodinitrile are hydrogenated to the corresponding primary amines. The reaction follows an outer-sphere mechanism.

METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION

The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under superheated conditions in either a microwave or oil bath.

A practical procedure for reduction of primary, secondary and tertiary amides to amines

A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and 1,1,3,3-tetramethyldisiloxane as reductant is described. The reaction is tolerant of numerous functional groups, and the amine products can often be isolated by direct crystallization as hydrochloride salts. The catalyst and silane are commercially available, air stable, and inexpensive, making the procedure accessible for both laboratory and large-scale applications. Copyright

A study of some molecularly imprinted polymers as protic catalysts for the isomerisation of α-pinene oxide to trans-carveol

A range of acidic Molecularly Imprinted Polymers (MIPs) were synthesised using the imprint molecule trans-carvyl amine as a transition state analogue for the selective isomerisation of α-pinene oxide to trans-carveol. The amine functionality of the imprint molecule was used to selectively position a sulfonic acid group in the MIP binding pocket utilising 4-styrene sulfonic acid as the functional monomer. Co-polymerisation with varying ratios of styrene and divinylbenzene afforded a range of MIPs which were tested for their ability to effect selective formation of trans-carveol from α-pinene oxide. Although successful imprinting was demonstrated in binding studies, it was shown that solvent effects were dominant in effecting selective formation of trans-carveol. Using DMF as solvent, up to 70% of the products from acid catalysed isomerisation of α-pinene oxide with the polystyrene MIPs were obtained via the necessary para menthyl tertiary carbocation, and industrially important trans-carveol was obtained in 45% yield.

Oxidative deprotection of diphenylmethylamines

(formula presented) The diphenylmethyl amino protecting group can be efficiently removed by initial oxidation of the amine to an imine by 2,3-dichloro-5,6-dicyanobenzoquinone. The resulting imine can then be easily hydrolyzed under mildly acidic conditions. This method is particularly well suited for the preparation of α-amino phosphinates and α-amino phosphonates.

A GENERAL PROCEDURE FOR MILD AND RAPID REDUCTION OF ALIPHATIC AND AROMATIC NITRO COMPOUNDS USING AMMONIUM FORMATE AS A CATALYTIC HYDROGEN TRANSFER AGENT

Various aliphatic and aromatic nitro compounds were selectively and rapidly reduced to their corresponding amino derivatives in very good yield using anhydrous ammonium formate as a catalytic hydrogen transfer agent.