54243-43-5

Usage

Uses

Used in Pharmaceutical Synthesis:
(Allylamino)acetonitrile is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and medications. Its role in the production process is crucial, as it contributes to the development of new and effective pharmaceutical compounds.
Used in Organic Chemical Reactions:
As a reagent, (Allylamino)acetonitrile is employed in organic chemical reactions to facilitate specific transformations and syntheses. Its presence can help drive reactions to completion or improve the yield of desired products.
Used in Chemical Compound Production:
(Allylamino)acetonitrile also serves as a building block in the production of other chemical compounds. Its versatile structure allows it to be incorporated into a wide range of molecules, making it a valuable component in the chemical industry.

Upstream product

• 50-00-0 formaldehyd 
• 74-90-8 hydrogen cyanide 
• 107-11-9 1-amino-2-propene 
• 544-92-3 copper(I) cyanide 
• 10017-11-5 allylammonium chloride 
• 151-50-8 potassium cyanide 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 56096-19-6 N-Allyl-3,5-dichloro-N-cyanomethyl-benzamide 
• 56096-22-1 N-Allyl-N-cyanomethyl-4-isopropyl-benzamide 
• 56096-15-2 N-Allyl-N-benzoylaminoacetonitrile 
• 56096-23-2 N-Allyl-N-cyanomethyl-4-methoxy-benzamide 
• 72524-91-5 N,N-diallyl-N-cyanomethylamine 
• 187737-37-7 propene 
• 849634-85-1 2-allyl-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile 
• 849549-30-0 2-allyl-4-(3-fluorophenyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrile 

Relevant academic research and scientific papers

BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

3-azabicyclo[3.1.0]hex-1-ylamines by Ti-mediated intramolecular reductive cyclopropanation of α-(N-allylamino)-substituted N,N-dialkylcarboxamides and carbonitriles

A variety of tris- and monoprotected derivatives with the 1-amino-3-azabicyclo[3.1.0]hexane and 1-amino-3-azabicy- clo[4.1.0]heptane skeleton 10 have been synthesized by intramolecular reductive cyclopropanation of α-(N-allylamino)-substituted N,N-dialkylcarboxamides 6, 8, and 9. Starting from derivatives of the naturally occurring amino acid serine (4a, 4b), the enantiomerically pure compounds 10a and 10b were obtained with endo/exo ratios of 2.5:1 (a) and 2:1 (b), in 26 and 30% overall yields, respectively. The unprotected bicyclic amines 11aa, 11ab, 11ba, and 11ad have been prepared by palladium-catalyzed hydrogenative deprotection of 10aa, 10ab, 10ba and 10ad, respectively, under acidic conditions, in 91, 95, 96, and 99% yields, respectively. X-ray crystal structure analyses of 10aa and 10ad in each case found an equatorial position of the N-benzyl group on the heterocycle and a common boat conformation for the 3-azabicyclo[3.1.0]hexane and 3-azabicyclo[4.1.0]heptane skeletons as a whole. One-step preparations of the bicyclic diamiries 11ac (41% yield) and 14a (48% yield) have been performed by application of the Kulinkovich-de Meijere procedure to the nitriles 12a and 12b. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Gas Phase Thermolysis of Allyl Cyanomethyl Amine, Diallyl Cyanomethyl Amine, Diethyl Cyanomethyl Amine, and Diethyl Propargyl Amine

The title amines were pyrolyzed in a stirred-flow reactor at 380 - 510 deg C, pressures of 8 - 15 torr and residence times of 0.3 - 2.4 s, using toluene as carrier gas.The substrates with an allyl group yielded propene and iminonitriles as reaction products.HCN is formed by decomposition of the iminonitriles.The first-order rate coefficients for propene formation fit the Arrhenius equations.Allyl cyanomethyl amine: k(s-1) = 1013.29 +/- 0.35exp(-189 +/- 5 kJ/mol RT) Diallyl cyanomethyl amine: k(s-1) = 1013.00 +/- 0.20exp(-183 +/- 3 kJ/mol RT) Diethyl cyanomethyl amine gave a 20:1 gas mixture of ethylene and ethane, plus HCN.The liquid product fraction contained mainly N-ethyl methanaldimine.The first-order rate coefficients for ethylene formation followed the Arrhenius equation k(s-1) = 1015.30 +/- 0.24exp(-226 +/- 3 kJ/mol RT) Diethyl propargyl amine decomposed cleanly into allene and N-ethyl ethanaldimine.The first-order rate coefficients for allene formation fit the Arrhenius equation k(s-1) = 1012.84 +/- 0.30exp(-168 +/- 4 kJ/mol RT).The results suggest that the above allyl and propargyl amines decompose unimolecularly by mechanisms involving six-center cyclic transition states.For diethyl cyanomethyl amine, a nonchain free radical mechanism is proposed.

SYNTHESE D'IMINES LINEAIRES NON-STABILISEES PAR REACTIONS GAZ-SOLIDE SOUS VIDE(1).

Unstabilized imines are synthetized in gram-scale by vacuum dehydrochlorination of N-chloroalkylamines and by vacuum dehydrocyanation of α-aminonitriles on solid base.All the new compounds are characterized at low temperature by 1H, 13C NMR and IR spectroscopy.