5426-65-3

Basic information

• Product Name: 3H-Pyrazol-3-one,4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl-
• Synonyms: Antipyrine,4-bromo- (6CI,7CI,8CI); 1-Phenyl-2,3-dimethyl-4-bromo-5-pyrazolone;4-Bromo-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; 4-Bromoantipyrine; NSC 14307
• CAS NO: 5426-65-3
• Molecular Formula: C₁₁H₁₁BrN₂O
• Molecular Weight: 267.1218
• Mol File: 5426-65-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 117°C
• Boiling Point: 309.3°Cat760mmHg
• Flash Point: 140.8°C
• Appearance: /
• Density: 1.525g/cm³
• Vapor Pressure: 0.000646mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane; Ethyl Acetate; Methanol
• CAS DataBase Reference: 3H-Pyrazol-3-one,4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one,4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl-(5426-65-3)
• EPA Substance Registry System: 3H-Pyrazol-3-one,4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl-(5426-65-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5426-65-3(Hazardous Substances Data)

Usage

General Description

3H-Pyrazol-3-one, 4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl- is a chemical compound that belongs to the pyrazole family. It is a brominated derivative of pyrazolone and has a molecular formula of C12H14BrN3O. 3H-Pyrazol-3-one,4-bromo-1,2-dihydro-1,5-dimethyl-2-phenyl- is used in the synthesis of pharmaceutical drugs and organic compounds due to its unique structure and reactivity. It has potential applications in the field of medicinal chemistry and drug discovery. Additionally, it may also be used as a building block for the creation of new chemical entities with diverse properties and functions.

InChI:InChI=1/C11H11BrN2O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3

Upstream product

• 56-23-5 tetrachloromethane 
• 128-08-5 N-Bromosuccinimide 
• 83-10-3 antipyric acid 
• 60-80-0 antipyrine 
• 506-68-3 bromocyane 
• 67-66-3 chloroform 
• 7726-95-6 bromine 

Downstream Products

• 5767-66-8 4-bromo-5-(bromomethyl)-1-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 
• 1672-63-5 4-hydroxyantipyrine 
• 37689-73-9 4-(hydroxy-diphenyl-methyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 122505-42-4 Methyl 1'-<4-hydroxy-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one>-2',3',4'-tri-O-acetyl-β-D-glucopyranuronate 
• 28070-40-8 4-Hydroxy-antipyrine β-D-glucuronide 

Relevant articles and documents

SCREENING METHODS AND THERAPEUTIC APPLICATIONS BASED ON BACTERIAL MOTILITY INHIBITION

The present invention relates to compounds for use in treating and/or preventing a bacterial infection or a condition associated with the bacterial infection, wherein the bacterial infection is caused by flagellated bacteria. The present invention further relates to a method of identifying compounds having bacterial anti-motility activity.

Photocatalytic Oxidative Bromination of Electron-Rich Arenes and Heteroarenes by Anthraquinone

The estimated excited oxidation potential of sodium anthraquinone-2-sulfonate (SAS) increases from 1.8 V to about 2.3 V vs SCE by protonation with Br?nsted acids. This increased photooxidation power of protonated anthraquinone was used for the regio-selective oxidative bromination of electron rich (hetero)arenes and drugs in good yield. The mild reaction conditions are compatible with many functional groups, such as double and triple bonds, ketones, amides and amines, hydroxyl groups, carboxylic acids and carbamates. Mechanistic investigations indicate the photooxidation of the arene followed by nucleophilic bromide addition as the likely pathway. (Figure presented.).

Direct Potentiometric Determination of Antipyrine and Some of Its Lanthanide Complexes Using N-Bromophthalimide

A direct potentiometric titration procedure is described, using N-bromophthalimide as the titrant, for the determination of antipyrine and some of its lanthanide complexes of the types and (ClO4)3, where Ln = La, Pr, Nd, Sm, Gd, T