5436-42-0Relevant academic research and scientific papers
Total Syntheses of Crinipellins Enabled by Cobalt-Mediated and Palladium-Catalyzed Intramolecular Pauson–Khand Reactions
Huang, Zhihui,Huang, Jun,Qu, Yongzheng,Zhang, Weibin,Gong, Jianxian,Yang, Zhen
supporting information, p. 8744 - 8748 (2018/07/14)
Efficient total syntheses of the naturally occurring, potent antibiotic compounds (?)-crinipellin A and (?)-crinipellin B are described. The key advanced intermediate, a fully functionalized tetraquinane core, was constructed by a novel thiourea/palladium-catalyzed Pauson–Khand reaction. This intermediate can serve as a common intermediate for the collective total synthesis of other members of the crinipellin family.
THE CLEMMENSEN REDUCTION OF ENOL ETHERS: CYCLOPROPYL ETHERS FROM MONO- AND DI-METHOXYCYCLOHEXA-1,4-DIENES
Elphimoff-Felkin, Irene,Sarda, Pierre
, p. 4425 - 4428 (2007/10/02)
Clemmensen reduction (zinc and hydrogen chloride in dry diethyl ether) of 1-methoxy- and 1,5-dimethoxy-cyclohexa-1,4-diene affords the cyclopropyl ethers, 1-methoxy- and 1,5-dimethoxy-bicyclohexane; in the presence of acetic anhydride, reduction of 6-acetyl-1-methoxy-6-methyl-cyclohexa-1,4-diene leads regiospecifically to 7-acetoxy-1-methoxy-6,7-dimethyl-bicyclohept-4-ene.
