5445-95-4

Basic information

• Product Name: (4-phenylcyclohexyl) acetate
• Synonyms: (4-phenylcyclohexyl) acetate
• CAS NO: 5445-95-4
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.29
• Mol File: 5445-95-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 307.8°C at 760 mmHg
• Flash Point: 132.7°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.000709mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: (4-phenylcyclohexyl) acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-phenylcyclohexyl) acetate(5445-95-4)
• EPA Substance Registry System: (4-phenylcyclohexyl) acetate(5445-95-4)

Safety Data

• Hazardous Substances Data: 5445-95-4(Hazardous Substances Data)

Usage

General Description

(4-phenylcyclohexyl) acetate, also known as PCHCA, is a chemical compound used in the manufacturing of pharmaceuticals, fragrances, and flavorings. It is a clear, colorless liquid with a slightly sweet, floral odor. PCHCA is primarily used as a chemical intermediate in the production of various products, including synthetic musks and other aromatic compounds. It is also used as a solvent for a variety of different substances, and as a flavoring agent in food and beverages. However, it is important to handle PCHCA with caution, as it can be harmful if swallowed, inhaled, or comes into contact with the skin. Additionally, it should be stored in a cool, dry place away from direct sunlight and heat to prevent degradation.

InChI:InChI=1/C14H18O2/c1-11(15)16-14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-6,13-14H,7-10H2,1H3

Upstream product

• 4894-75-1 1-phenyl-4-cyclohexanone 
• 141-78-6 ethyl acetate 
• 5769-13-1 4-phenyl-cyclohexanol 
• 108-24-7 acetic anhydride 
• 84454-61-5 trans-4-chlorocyclohexyl acetate 
• 100-59-4 phenylmagnesium chloride 
• 5437-46-7 trans-4-phenylcyclohexanol 
• 506-96-7 Acetyl bromide 
• 23923-62-8 cis e trans-4-fenilacetilcicloesano 

Downstream Products

• 159737-83-4 trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol 
• 55077-82-2 Acetic acid 4-[4-(1,2,2-tricyano-ethyl)-phenyl]-cyclohexyl ester 
• 55077-83-3 2-[4-(4-Hydroxy-cyclohexyl)-phenyl]-succinic acid 
• 63476-59-5 [4-(4-Acetoxy-cyclohexyl)-phenyl]-acetic acid methyl ester 
• 63476-43-7 2-[4-(4-Oxo-cyclohexyl)-phenyl]-propionic acid 
• 63476-40-4 2-[4-(4-Hydroxy-cyclohexyl)-phenyl]-propionic acid 
• 63476-39-1 [4-(4-hydroxy-cyclohexyl)-phenyl]-acetic acid 
• 5437-46-7 trans-4-phenylcyclohexanol 

Relevant articles and documents

Improved Process for the Palladium-Catalyzed C-O Cross-Coupling of Secondary Alcohols

An improved protocol for the Pd-catalyzed C-O cross-coupling of secondary alcohols is described. The use of biaryl phosphine L2 as the ligand was key to achieving efficient cross-coupling of (hetero)aryl chlorides with only a 20percent molar excess of the alcohol. Additionally, we observed an unusual reactivity difference between an electron-rich aryl bromide and the analogous aryl chloride, and deuterium-labeling suggested that currently unidentified pathways for reduction play an important role in explaining this disparity.

One-pot sequence for reductive-acetylation of carbonyl compounds with (N-methylimidazole)(tetrahydroborato)zinc complex

Reductive-acetylation of variety of aliphatic and aromatic aldehydes and ketones, α,β-unsaturated carbonyl compounds are examined efficiently with (N-methylimidazole)(tetrahydroborato)zinc complex, [Zn(BH4) 2(nmi)], under mild condition in THF at room temperature or reflux conditions. The corresponding acetates were obtained in excellent yields (90-98 %).

O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them

Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I STR1 wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between the denote 5- to 7-membered saturated, monocyclic or heterocyclic rings which may optionally also be interrupted by an oxygen or sulfur atom or by an imino group, R3, R4, R5 and R6 denote hydrogen or lower alkyl, R5 additionally denotes lower alkoxy, R7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl having up to 17 carbon atoms.