54458-44-5Relevant academic research and scientific papers
Acylation of a transient Ti(IV)-enolate by acyl halides and anhydrides. Facile synthesis of α-hydroxy-β-ketoesters
Clerici, Angelo,Clerici, Laura,Porta, Ombretta
, p. 11037 - 11044 (1996)
Regioselective C-acylation at the carbonyl carbon of methyl phenylglyoxylate 1 occurs by reaction with a variety of acyl halides 3 and anhydrides 4 in the presence of TiCl3/py system in THF at room temperature. α-Hydroxy-β-ketoesters 5 are the
Addition of mixed (Alkenyl)dialkylzincates to vicinal diketo esters
Selter, Lars,Harms, Klaus,Koert, Ulrich
, p. 1215 - 1230 (2017/12/07)
Methods for the regioselective alkylation, arylation, and alkenylation of α,β-diketo esters using organozinc reagents are reported. Alkylation and arylation at the α-position is possi-ble using diorganozinc compounds. Alkenylation can be achieved using mixed (alkenyl)dineopentylzincates.
Efficient Synthesis of α-Hydroxy-β-ketoesters from Methyl Phenylglyoxalate and Acid Chlorides mediated by Titanium Trichloride
Araneo, Silvia,Clerici, Angelo,Porta, Ombretta
, p. 2213 - 2216 (2007/10/02)
Methyl phenylglyoxalate and acid chlorides undergo rapid condensation reactions on treatment with a TiCl3-THF/CH2Cl2 solution, in the presence of pyridine, at room temperature.
