5446-19-5

Basic information

• Product Name: methyl 2-[acetyl(2-methoxy-2-oxoethyl)amino]benzoate
• CAS NO: 5446-19-5
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.2619
• Mol File: 5446-19-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 409.7°C at 760 mmHg
• Flash Point: 201.6°C
• Density: 1.231g/cm³
• Vapor Pressure: 6.36E-07mmHg at 25°C
• Refractive Index: 1.544
• CAS DataBase Reference: methyl 2-[acetyl(2-methoxy-2-oxoethyl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[acetyl(2-methoxy-2-oxoethyl)amino]benzoate(5446-19-5)
• EPA Substance Registry System: methyl 2-[acetyl(2-methoxy-2-oxoethyl)amino]benzoate(5446-19-5)

Safety Data

• Hazardous Substances Data: 5446-19-5(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 13622-59-8 N-(2-methoxycarbonylphenyl)glycine methyl ester 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 69808-71-5 1H-indole-2-carboxylic acid methylamide 

Relevant articles and documents

Stereogenic: Cis -2-substituted- N -acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation

Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines to cis-2-substituted-N-acetyl-3-hydroxyindolines is reported. Using the homochiral {Ru[TfDPEN](p-cymene)} catalyst with S/C = 400 in a HCO2H/Et3N mixture, up to >99.9% ee and >99:1 dr are obtained with high yields (79-98%). This method provides the first example of preparing enantiomerically pure indolines through asymmetric transfer hydrogenation (ATH).