69808-71-5Relevant academic research and scientific papers
Cu(OAc)2-Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α-Acylmethyl Malonates with Indole Derivatives to Access 3-Functionalized Indoles and Polycyclic Indoles
Zhou, Li-Jin,Wang, Kun,Guan, Hong-Rong,Zheng, An-Qi,Yang, Hai-Tao,Miao, Chun-Bao
, p. 7925 - 7938 (2020/07/25)
A Cu(OAc)2-promoted oxidative cross-dehydrogenative coupling reaction of α-acylmethyl malonates with indole derivatives was developed. In the case of indoles, the regioselective coupling products were formed through a sequential dehydrogenation-addition-dehydrogenation process. When a second nucleophilic center was located in the 2-position of indoles, further successive nucleophilic cyclization occurred to give polycyclic indole derivatives. The Cu(OAc)2 was proved to act as not only an oxidant but also a catalyst.
Cu(OAc)2-Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides
Mao, Peng-Fei,Zhou, Li-Jin,Zheng, An-Qi,Miao, Chun-Bao,Yang, Hai-Tao
supporting information, p. 3153 - 3157 (2019/05/10)
A Cu(OAc)2-promoted cascade reaction of malonate-tetherd acyl oximes with indoles, indole-2-alcohols, or indole-2-carboxmides provides facile access to polysubstituted 3-pyrrolin-2-ones. The reaction features the generation of two adjacent elec
Total synthesis and structural revision of a mangrove alkaloid
Green, Michael T.,Peczkowski, Gary R.,Al-Ani, Aneesa J.,Benjamin, Sophie L.,Simpkins, Nigel S.,Jones, Alan M.
, p. 48754 - 48758 (2017/11/06)
We report the total synthesis of an alkaloid isolated from the mangrove fungi Hypocrea virens, based on the originally claimed structure, via a photochemical sequence. Inconsistencies between data sets led to a revision of the proposed structure followed by a concise synthetic sequence to deliver the revised natural product.
A use of the carboxamides aryl carbonyl aminolysis method of preparing amide
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Paragraph 0030; 0032-0035, (2016/10/10)
The invention discloses a method for preparing amides via a decarbonylation ammonolysis reaction of aryl ester and formamide. The method comprises the following steps: dissolving a palladium catalyst, aryl ester and formamide in a solvent, and stirring fo
Synthesis of heteroarylogous 1H-indole-3-carboxamidines via a three-component interrupted Ugi reaction
La Spisa, Fabio,Meneghetti, Fiorella,Pozzi, Beatrice,Tron, Gian Cesare
, p. 489 - 496 (2015/02/19)
A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
Efficient and general synthesis of oxazino[4,3-a]indoles by cascade addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl sulfonium salts
An, Jing,Chang, Ning-Jie,Song, Li-Dong,Jin, Yu-Qin,Ma, Ying,Chen, Jia-Rong,Xiao, Wen-Jing
supporting information; experimental part, p. 1869 - 1871 (2011/03/22)
An efficient and general approach to oxazino[4,3-a]indole architectures is described. The addition-cyclization cascade of (1H-indol-2-yl)methanols with vinyl sulfonium salts affords oxazino[4,3-a]indole derivatives in high yields.
THERAPEUTIC AGENTS, AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 188, (2010/11/27)
In part, the present invention is directed to antibacterial compounds
FAB I INHIBITORS
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, (2008/06/13)
Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
