54485-06-2Relevant academic research and scientific papers
Stereochemistry of phenyl(amino)alkanols
Grasshoff,Haller
, p. 493 - 500 (1986)
Diastereomeric amino alcohols, prepared by the reduction of corresponding ketones with complex metal hydrides, can be cyclisized in a stereospecific manner. Conclusions on the relative configurations of the tetrahydrofurane derivates thus obtained were made on the basis of 1H-NMR data.
Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones
Wang, Pengzhi,Fitzpatrick, Keegan P.,Scheidt, Karl A.
, p. 518 - 524 (2021/12/16)
N-heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C?C bonds in the synthesis of substituted ketones under single-electron processes. Despite these recent reports, there still remains a need to increase the utility and practicality of these reactions by exploring new radical coupling partners. Herein, we report the synthesis of γ-aryloxyketones via combined NHC/photoredox catalysis. In this reaction, an α-aryloxymethyl radical is generated via oxidation of an aryloxymethyl potassium trifluoroborate salt, which is then added into styrene derivatives to provide a stabilized benzylic radical. Subsequent radical-radical coupling reaction with an azolium radical affords the γ-aryloxy ketone products. (Figure presented.).
Cu-catalyzed intramolecular aryl-etherification reactions of alkoxyl alkynes with diaryliodonium salts via cleavage of a stable C-O bond
Chen, Jing,Chen, Chao,Chen, Junjie,Wang, Guohua,Qu, Hongmei
, p. 1356 - 1359 (2015/02/05)
A novel Cu-catalyzed intramolecular aryl-etherification reaction of alkoxyl alkynes with diaryliodonium salts is realized. The reactions proceed smoothly to produce valuable oxo-heterocycles with readily available linear starting materials via cleavage of a stable C-O bond. This journal is
