5451-60-5

Basic information

• Product Name: octan-2-yl formate
• Synonyms: 2-octanol, formate; Octan-2-yl formate
• CAS NO: 5451-60-5
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.238
• Mol File: 5451-60-5.mol

Chemical Properties

• Boiling Point: 195.9°C at 760 mmHg
• Flash Point: 71.8°C
• Density: 0.873g/cm³
• Vapor Pressure: 0.409mmHg at 25°C
• Refractive Index: 1.417
• CAS DataBase Reference: octan-2-yl formate(CAS DataBase Reference)
• NIST Chemistry Reference: octan-2-yl formate(5451-60-5)
• EPA Substance Registry System: octan-2-yl formate(5451-60-5)

Safety Data

• Hazardous Substances Data: 5451-60-5(Hazardous Substances Data)

Upstream product

• 4128-31-8 rac-octan-2-ol 
• 68-12-2 N,N-dimethyl-formamide 
• 3282-30-2 pivaloyl chloride 
• 111-87-5 octanol 
• 3724-43-4 Vilsmeier reagent 
• 64-18-6 formic acid 
• 2258-42-6 formyl acetic anhydride 
• 557-35-7 2-bromooctane 
• 18023-52-4 trimethyl-(1-methyl-heptyloxy)-silane 
• 109-94-4 formic acid ethyl ester 
• 56-23-5 tetrachloromethane 
• 111-66-0 oct-1-ene 

Downstream Products

• 4128-31-8 rac-octan-2-ol 

Relevant articles and documents

Method of manufacturing imidoyl diazidosulfochloride compd. various compd. and manufacturing method of using the same

PROBLEM TO BE SOLVED: To provide a new production method for synthesizing an imidoyl chloride compound dispensing with chlorination agents having poor handleability, to provide a method for producing various compounds in high yield and purity by using the imidoyl chloride compound, and to provide a method for isolating the imidoyl chloride compound in high efficiency and purity from a mixture of the imidoyl chloride compound and a phthalic anhydride compound.SOLUTION: The method for producing the imidoyl chloride compound comprises reaction of a specific amide compound with a specific phthaloyl chloride compound to produce a specific imidoyl chloride compound.

Formylation of amines and alcohols using aminopropylated mesoporous SBA-15 silica (APMS) as an efficient and recyclable catalyst

Aminopropylated mesoporous SBA-15 silica (APMS) is introduced as a new, recyclable and efficient catalyst for the formylation of a variety of amines and alcohols by using readily available formic acid under solvent-free conditions.

Corona-induced photoxidation of alcohols and hydrocarbons over TiO 2 in the absence of a UV light source - A novel and environmentally friendly method for oxidation

Corona-induced photooxidation is a novel oxidation methodology for the efficient oxidation of alcohols and hydrocarbons utilizing the advantage of both the high oxidizing power of ozone formed in the reactor as well as the photooxidation capability of the UV light generated during the corona discharge. The Royal Society of Chemistry 2005.

Silphos [PCl3-n(SiO2)n]: A heterogeneous phosphine reagent for formylation and acetylation of alcohols and amines with ethyl formate and acetate

Alcohols and amines are formylated and acetylated in the presence of Silphos [PCl3-n(SiO2)n] in ethyl formate and ethyl acetate in high to excellent yields. This procedure provides a method to separate the product by a simple filtration.

Esterification of alkene with cerium(IV) sulfate in carboxylic acid

Reaction of alkenes [cyclohexene (1), cycloheptene (2), cyclooctene (3), 1-heptene (4), 1-octene (5), styrene (6), 1,7-octadiene (7), indene (8), and 1,2-dihydronaphthalene (9)] with cerium(IV) sulfate (CS) in carboxylic acids [formic acid, acetic acid, and propionic acid] readily yielded the corresponding carboxylic esters. This addition reaction follows the Markovnikov rule. This reaction provides a new simple method for preparing carboxylic esters from alkenes. It was also found that this method is useful for formylation.

Catalytic esterification of alcohols, carboxylic acids and transesterification reactions with cerium(IV) triflate

Esterification reactions of alcohols with acetic, chloroacetic, trifluoroacetic, propionic, stearic, and benzoic acids were catalyzed with Ce(OTf)4 in a solvent or under solvent-free conditions with high yields. The formylation and acetylation of primary and secondary alcohols were also easily achieved in ethyl formate and ethyl acetate. A high retention of the configuration was observed in the acetylation and formylation of (-)-menthol.

Conversion of trimethylsilyl ethers to acetyl or formyl esters with TiCl4

A simple method is described for the efficient conversion of trimethylsilyl ethers to their corresponding acetyl and formyl esters in refluxing ethyl acetate or ethyl formate in the presence of TiCl4.

Selective acetylation of primary alcohols: Acetyl and formyl transfer reactions with copper(II) salts

The efficient esterification of primary and secondary alcohols in acetic acid was achieved in the presence of Cu(NO3)2. 3H20 in high yields. Selective acetylation of primary in the presence of secondary hydroxyl groups in excellent yields were performed in EtOAc. Formylation of primary and secondary alcohols was also achieved easily in ethyl formate. High retention of configuration was observed in the acetylafion and formylation of (-) menthol in the presence of Cu(NO3)2. 3H20 and Cu(OAC)2. H2O.

Nucleophilic Substitution Reactions of (Alkoxymethylene)dimethylammonium Chloride

The use of imidate esters as potential replacements for diethyl azodicarboxylate and triphenylphosphine in the Mitsunobu reaction is described. A series of secondary alcohols were allowed to react with (chloromethylene)dimethylammonium chloride, generated from dimethylformamide (DMF) and oxalyl chloride, to give imidate esters. Reaction of these salts with potassium benzoate or potassium phthalimide gave the products of SN2 substitution in excellent yields with clean inversion of stereochemistry. Optimization of reaction conditions is discussed as a means to increase the atom economy of the process by minimizing the quantity of nucleophile required.