5452-06-2

Basic information

• Product Name: 2-chloroethyl 4-methoxybenzoate
• CAS NO: 5452-06-2
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.6455
• Mol File: 5452-06-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 322.3°C at 760 mmHg
• Flash Point: 137°C
• Density: 1.197g/cm³
• Vapor Pressure: 0.000281mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 2-chloroethyl 4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloroethyl 4-methoxybenzoate(5452-06-2)
• EPA Substance Registry System: 2-chloroethyl 4-methoxybenzoate(5452-06-2)

Safety Data

• Hazardous Substances Data: 5452-06-2(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 107-07-3 2-chloro-ethanol 
• 100-09-4 4-methoxybenzoic acid 
• 849-83-2 bis(4-methoxybenzoyl) peroxide 
• 107-06-2 1,2-dichloro-ethane 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 104-93-8 p-methylanizole 
• 123-11-5 4-methoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 

Downstream Products

• 10367-84-7 N,N-diethylamino ethyl p-methoxybenzoate 
• 109509-32-2 [2-(4-methoxy-benzoyloxy)-ethyl]-trimethyl-ammonium; iodide 
• 100-09-4 4-methoxybenzoic acid 
• 62557-46-4 4-methoxy-benzoic acid-(2-piperidino-ethyl ester) 

Relevant articles and documents

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

Cobalt-Catalyzed Esterification of Amides

The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.

Synthetic method of an ester compound

The invention discloses a synthetic method of an ester compound and belongs to the technical field of organic synthesis. The synthetic method includes the steps of: dissolving an aldehyde compound (1) and a halogenated hydrocarbon compound (2) in a solvent, adding an oxidant and a catalyst, and performing a reaction at 60-100 DEG C to obtain the target product ester compound (3). A reaction equation of the synthetic method is represented as follows. The method, compared with the prior art, has the following advantages: 1) the raw materials are easy to obtain and are low in cost; 2) the reaction conditions are mild, operations are simple, and reaction time is short; and 3) a substrate has wide available range and can be used for synthesis of various ester compounds.