545385-94-2Relevant academic research and scientific papers
One-pot synthesis of malononitriles by free radical reactions of ylidenemalononitrile with Et3B and iodoalkane in a water-ether biphase medium
Tu, Zhijay,Lin, Chunchi,Jang, Yaochung,Jang, Yeong-Jiunn,Ko, Shengkai,Fang, Hulin,Liu, Ju-Tsung,Yao, Ching-Fa
, p. 6133 - 6137 (2006)
The one-pot synthesis of malononitrile derivatives 4, 6, and 7 in moderate to high yields by the reaction of ylidenemalononitriles 3, prepared in situ from carbonyl compounds 1 and malononitrile 2 in the presence of ammonium acetate in aqueous solution at
A one-pot preparation of 1,3-disubstituted azetidines
Hillier, Michael C.,Chen, Cheng-Yi
, p. 7885 - 7887 (2007/10/03)
(Chemical Equation Presented) A straightforward synthesis of 1,3-disubstituted azetidines has been accomplished via the alkylation of a primary amine with the bis-triflate of a 2-substituted-1,3-propanediol species. This transformation is carried out in o
Triethylaluminum- or triethylborane-induced free radical reaction of alkyl iodides and α,β-unsaturated compounds
Liu, Jing-Yuan,Jang, Yoeng-Jiunn,Lin, Wen-Wei,Liu, Ju-Tsung,Yao, Ching-Fa
, p. 4030 - 4038 (2007/10/03)
A series of α,β-unsaturated compounds, 1a-c, 9, 13, and 17, were used as reactants in free radical conjugate addition reactions with different radicals generated from alkyl iodides such as 3, 4, or 5 in the presence of triethylborane-oxygen in air or via the use of triethylaluminum-benzoyl peroxide as a free radical initiator. When the reactions were carried out using triethylborane-air, the products, in most cases, were clean and were easily purified. However, higher yields of the 1,4-adducts and less side reactions occurred when less reactive substrates were used as Michael acceptors in reactions with triethylaluminum-benzoyl peroxide and alkyl iodide under similar conditions. A mechanism for this is proposed in Scheme 1.
