54549-74-5

Basic information

• Product Name: Acetic acid 4-formylbenzyl ester
• Synonyms: 4-(Acetoxymethyl)benzaldehyde;4-[(Acetyloxy)methyl]benzaldehyde;Acetic acid 4-formylbenzyl ester
• CAS NO: 54549-74-5
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 54549-74-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetic acid 4-formylbenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 4-formylbenzyl ester(54549-74-5)
• EPA Substance Registry System: Acetic acid 4-formylbenzyl ester(54549-74-5)

Safety Data

• Hazardous Substances Data: 54549-74-5(Hazardous Substances Data)

Upstream product

• 119991-79-6 4-(methoxymethyl)benzyl acetate 
• 67003-50-3 4-(Methoxymethyl)benzoic acid 
• 75-36-5 acetyl chloride 
• 52010-97-6 4-(hydroxylmethyl)benzaldehyde 
• 2216-45-7 p-methylbenzyl alcohol acetate 
• 589-29-7 p-xylylene glycol 
• 108-24-7 acetic anhydride 
• 106-42-3 para-xylene 
• 623-27-8 terephthalaldehyde, 
• 81172-89-6 terephthalaldehyde mono(diethylacetal) 
• 125734-44-3 4-(hydroxymethyl)benzaldehyde diethyl acetal 
• 538316-01-7 1,1-dimethylethyl 4-(methoxymethyl)benzoate 
• 1719-82-0 p-methoxymethylbenzoic acid methyl ester 
• 62172-89-8 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane 

Downstream Products

• 219828-44-1 Acetic acid 4-((R)-2-tert-butylsulfanylcarbonyl-1-hydroxy-ethyl)-benzyl ester 
• 485817-68-3 4-(4-acetoxymethylphenyl)-4-hydroxy-2-methylenebutanoic acid 
• 357262-43-2 (+/-)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid 
• 485817-69-4 4-(4-acetoxymethylphenyl)-2-methylene-4-oxobutanoic acid 
• 485817-70-7 4-(4-acetyloxymethylphenyl)-2-acetylthiomethyl-4-oxobutanoic acid 
• 1279701-22-2 8-(4-(1-hydroxy-2-nitroethyl)phenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene 
• 930117-83-2 4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate 
• 1592-12-7 4-acetoxymethylstyrene 

Relevant articles and documents

Large-scale synthesis of a substituted d -phenylalanine using asymmetric hydrogenation

A synthetic route to an N-BOC d-phenylalanine pharmaceutical intermediate suitable for rapid scale-up to 150-kg scale was required. A seven-step route based on asymmetric hydrogenation of an N-acetyl dehydroamino-acid was developed. Starting with terephthalic dialdehyde, monoreduction of one aldehyde group, Erlenmeyer condensation, and ring-opening/O-deacetylation with methanol provided the 4-(hydroxymethyl)-substituted dehydrophenylalanine hydrogenation substrate. Asymmetric hydrogenation of this enamide using [((R,R)-Ethyl-DuPhos) Rh(COD)BF4 proceeded in high enantiomeric excess. Subsequently, the cis-2,6-piperidyl group was introduced by mesylation/displacement, the BOC group was introduced, and acetyl and methyl ester groups were removed by basic hydrolysis. This route was used to manufacture 150 kg of the BOC amino acid 1.

Oxidation of benzylic alcohols and ethers to carbonyl derivatives by nitric acid in dichloromethane

Nitric acid in dichloromethane may be successfully employed for the oxidation of benzylic alcohols and ethers to the corresponding carbonyl compounds. The proposed method proved to be of general applicability, affording very good yields of aldehydes and ketones and showing interesting chemoselectivity in many instances, allowing competitive aromatic nitration to be avoided, as well as - in the case of aldehydes - any further oxidation to carboxylic acids. The reaction probably proceeds by a radical mechanism, the active species in the oxidation process being NO2. Competitive formation of nitro esters was observed in some cases, whereas poor results were obtained with allylic and non-benzylic substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Highly efficient aerobic oxidation of benzylic and allylic alcohols by a simple catalyst system of [RuCl2(p-cymene)]2/Cs2CO3

A new catalyst system of [RuCl2(p-cymene)]2/Cs2CO3 has been disclosed for highly efficient aerobic oxidation of activated alcohols to the corresponding carbonyl compounds, which is characterized by its high selectivity and activity, operational simplicity, and low air and moisture sensitivity. (C) 2000 Elsevier Science Ltd.