5470-75-7

Basic information

• Product Name: 6-chloroquinolin-8-amine
• Synonyms: 6-chloroquinolin-8-amine;6-Chloro-8-quinolinamine;6-Chloro-8-aminoquinoline;8-Amino-6-chloroquinoline;8-Quinolinamine, 6-chloro-;Nsc 27981;NSC 2798
• CAS NO: 5470-75-7
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 5470-75-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 357.7°Cat760mmHg
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.363g/cm³
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 6-chloroquinolin-8-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloroquinolin-8-amine(5470-75-7)
• EPA Substance Registry System: 6-chloroquinolin-8-amine(5470-75-7)

Safety Data

• Hazardous Substances Data: 5470-75-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 5470-75-7 differently. You can refer to the following data:
1. 6-chloroquinolin-8-amine is a di-substituted quinoline derivative used in the preparation fungitoxic analogs.
2. 6-Chloro-8-aminoquinoline is a di-substituted quinoline derivative used in the preparation fungitoxic analogs.

InChI:InChI=1/C9H7ClN2/c10-7-4-6-2-1-3-12-9(6)8(11)5-7/h1-5H,11H2

Upstream product

• 612-57-7 6-chloroquinoline 
• 89-63-4 4-Chloro-2-nitroaniline 
• 7647-01-0 hydrogenchloride 
• 68527-66-2 6-chloro-8-nitroquinoline 

Downstream Products

• 27318-90-7 1,10-phenanthroline-5,6-dione 
• 703-66-2 6,8-Dichloroquinoline 
• 4199-89-7 5-Chloro-1,10-phenanthroline 

Relevant articles and documents

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Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor

The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.