68527-66-2

Basic information

• Product Name: 6-chloro-8-nitroquinoline
• Synonyms: 6-chloro-8-nitroquinoline
• CAS NO: 68527-66-2
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.6012
• Mol File: 68527-66-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 343.8°Cat760mmHg
• Flash Point: 161.7°C
• Appearance: /
• Density: 1.484g/cm³
• Vapor Pressure: 0.000136mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-chloro-8-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-8-nitroquinoline(68527-66-2)
• EPA Substance Registry System: 6-chloro-8-nitroquinoline(68527-66-2)

Safety Data

• Hazardous Substances Data: 68527-66-2(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

InChI:InChI=1/C9H5ClN2O2/c10-7-4-6-2-1-3-11-9(6)8(5-7)12(13)14/h1-5H

Upstream product

• 89-63-4 4-Chloro-2-nitroaniline 
• 612-57-7 6-chloroquinoline 
• 477601-08-4 6-methoxy-N-{2-[3-(2-naphthyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]ethyl}-8-quinolinamine 
• 1310-73-2 sodium hydroxide 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 107-02-8 acrolein 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 56-81-5 glycerol 
• 881-51-6 N-(4-chloro-2-nitrophenyl)-acetamide 

Downstream Products

• 578-66-5 8-amino quinoline 
• 5470-75-7 8-amino-6-chloroquinoline 
• 703-66-2 6,8-Dichloroquinoline 
• 158117-56-7 8-amino-3,6-dichloroquinoline 
• 183543-65-9 8-Amino-3-bromo-6-chloroquinoline 
• 183543-61-5 3-Bromo-6-chloro-8-nitroquinoline 
• 27318-90-7 1,10-phenanthroline-5,6-dione 
• 4199-89-7 5-Chloro-1,10-phenanthroline 

Relevant articles and documents

Merging Annulation with Ring Deconstruction: Synthesis of (E)-3-(2-Acyl-1 H-benzo[ d]imidazol-4-yl)acrylaldehyde Derivatives via I2/FeCl3-Promoted Dual C(sp3)-H Amination/C-N Bond Cleavage

An unprecedented I2/FeCl3-promoted cascade reaction of aryl methyl ketones with 8-aminoquinolines for the convenient synthesis of (E)-3-(2-acyl-1H-benzo[d]imidazol-4-yl)acrylaldehydes was developed by merging annulation with ring deconstruction. This novel strategy unlocked the new reactivity of 8-aminoquinolines and provided an attractive platform for the ring opening of unactivated N-heteroaromatic compounds. Preliminary mechanistic investigation suggested that dual C(sp3)-H amination/C-N bond cleavage were key reaction steps. Furthermore, late-stage modification of the obtained products successfully delivered pyrazole and isoxazole derivatives, increasing the practicability and application potential of this methodology in organic synthesis.

Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation

Disclosed herein are angiogenesis inhibitors represented by formula (I) or formula (II): The variables for formulas (I) and (II) are defined herein.

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.