549-02-0

Usage

Uses

Used in Pharmaceutical Industry:
10β,17β-dihydroxyestra-1,4-dien-3-one is used as a hormone replacement therapy for [application reason] managing symptoms of menopause, osteoporosis, and other conditions related to estrogen deficiency.
Used in Research Applications:
10β,17β-dihydroxyestra-1,4-dien-3-one is used as a research compound for [application reason] studying the effects of estrogen on various physiological processes and the development of new drugs targeting estrogen receptors.
Used in Neurodegenerative Disease Treatment:
10β,17β-dihydroxyestra-1,4-dien-3-one is used as a potential therapeutic agent for [application reason] inducing an increase of estrogen levels in 3K transgenic mice with Parkinson's disease (PD)-like motor syndrome, which may help alleviate symptoms and improve the quality of life for patients with neurodegenerative diseases.

Biochem/physiol Actions

DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality.

Upstream product

• 2269-01-4 10,17β-diacetoxy-estra-1,4-dien-3-one 
• 19590-55-7 2,4-dibromoestradiol 
• 1743-60-8 17-β-estradiol 17-acetate 
• 108681-22-7 2,4-dibromo-10β,17β-dihydroxy-1,4-estradien-3-one 
• 50-28-2 estradiol 
• 4147-11-9 10-acetoxy-17β-hydroxy-estra-1,4-dien-3-one 

Downstream Products

• 6562-28-3 3-(2,4-dinitro-phenylazo)-estra-1,3,5(10)-trien-17β-ol 

Relevant academic research and scientific papers

Practical one-pot conversion of 17β-estradiol to 10β-hydroxy- (p-quinol) and 10β-chloro-17β-hydroxyestra-1,4-dien-3-one

An efficient one-pot procedure for the preparation of 10β,17β-dihydroxyestra-1,4-dien-3-one (p-quinol, 1, 75%) is reported, involving oxidation of 17β-estradiol with potassium permanganate. Similar treatment of 17β-estradiol with sodium chlorite led to 10β-chloro-17β-hydroxyestra-1,4-dien-3-one (2) in 44% yield along with smaller amounts 4-chloro-10β,17β-dihydroxyestra-1,4-dien-3-one (3), 2,10β-dichloro-17β-hydroxyestra-1,4-dien-3-one (4), and 4,10β-dichloro-17β-hydroxyestra-1,4-dien-3-one (5).

Organophotocatalytic Aerobic Oxygenation of Phenols in a Visible-Light Continuous-Flow Photoreactor

A mild photocatalytic phenol oxygenation enabled by a continuous-flow photoreactor using visible light and pressurized air is described herein. Products for wide-ranging applications, including the synthesis of vitamins, were obtained in high yields by precisely controlling principal process parameters. The reactor design permits low organophotocatalyst loadings to generate singlet oxygen. It is anticipated that the efficient aerobic phenol oxygenation to benzoquinones and p-quinols contributes to sustainable synthesis.