54966-47-1

Basic information

• Product Name: 4-Oxo-4-phenyl-2-butynoic acid ethyl ester
• Synonyms: 4-Oxo-4-phenyl-2-butynoic acid ethyl ester
• CAS NO: 54966-47-1
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol File: 54966-47-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Oxo-4-phenyl-2-butynoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxo-4-phenyl-2-butynoic acid ethyl ester(54966-47-1)
• EPA Substance Registry System: 4-Oxo-4-phenyl-2-butynoic acid ethyl ester(54966-47-1)

Safety Data

• Hazardous Substances Data: 54966-47-1(Hazardous Substances Data)

Upstream product

• 37174-94-0 ethyl 4-phenylbut-3-ynoate 
• 623-47-2 propynoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 72036-37-4 ethyl 4-hydroxy-4-phenylbut-2-ynoate 
• 16205-84-8 ethyl 3-(trimethylsilyl)propynoate 
• 98-88-4 benzoyl chloride 
• 152126-77-7 ethyl 3,4-dioxo-4-phenyl-2-triphenylphosphoranylidenebutanoate 
• 43165-51-1 sodium benzoylformate 
• 25726-04-9 phenylglyoxylyl chloride 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 

Downstream Products

• 653605-66-4 ethyl (E)-4-oxo-4-phenyl-2-(pyrrolidin-1-yl)but-2-enoate 
• 653605-67-5 ethyl (E)-2-(morpholin-4-yl)-4-oxo-4-phenylbut-2-enoate 

Relevant articles and documents

Synthesis of trisubstituted allenamides utilizing 1,2-rearrangement of dialkoxyphosphoryl moiety under Br?nsted base catalysis

A new method for the synthesis of trisubstituted allenamides was developed by utilizing the 1,2-rearrangement of a dialkoxyphosphoryl moiety from carbon to nitrogen under Br?nsted base catalysis. The reaction would involve the catalytic generation of an α-amino propargyl anion through the key rearrangement, the addition to an electrophile at the α-position of the anionic intermediate, and the unprecedented rearrangement of a phosphoramidate moiety of the adduct, providing trisubstituted allenamides that are difficult to synthesize by using conventional methods.

Synthesis of N-methoxy-N-methyl-β-enaminoketoesters: New synthetic precursors for the regioselective synthesis of heterocyclic compounds

Weinreb amides react with the lithium or sodium acetylide of ethyl propynoate in a hitherto unexplored acyl substitution-conjugate addition sequence to furnish (E)-N-methoxy-N-methyl-β-enaminoketoesters. This approach provides a diverse entry to densely functionalized heterocyclic compounds, including pyrazoles through regioselective cyclocondensations with hydrazines in a microwave-assisted reaction.

Oxalylmethylenephosphoranes: III. Synthesis and Flash Vacuum Pyrolysis of Ethyl 4-Aryl-3-triphenylphosphoranylidene-2,4-dioxobutanoates

Ethyl 4-aryl-3-triphenylphosphoranylidene-2,4-dioxobutanoates were obtained by C-acylation of (aroylmethylene)(triphenyl)phosphorane with ethyl oxalyl chloride. Under conditions of vacuum flash pyrolysis at 500°C the former eliminate triphenylphosphine oxide to give ethyl 4-aryl-4-oxo-2-butynoates.