653605-66-4Relevant academic research and scientific papers
Catalyst-Free and Oxidant-Free Cascade Difluoroalkylation and Controllable C?F Bond Activation of Aryl Enol Acetates for the Synthesis of β-Fluoroenones and β-Enaminones
Li, Wenshuang,Liu, Ruyan,Li, Ruonan,Wang, Shihaozhi,Li, Dianjun,Yang, Jinhui
supporting information, p. 5266 - 5271 (2021/09/25)
Aryl enol acetates and DMF could promote radical difluoroalkylation of aryl enol acetates to generate α,α-difluoro-γ-ketoacetates without a catalyst, an oxidant, or a base. When using different bases, β-fluoroenones and β-enaminones were synthesized by controllable C?F bond activation. These transformations provide an alternative method for the cascade difluoroalkylation and C?F bonds activation of aryl enol acetates. (Figure presented.).
Alkoxycarbonyl-Substituted 3-Trifloxypropene Iminium Salts and Iminium-Substituted Δ2,3-Butenolides: Synthesis and Reactivity toward Nucleophiles
Nikolai, Joachim,Maas, Gerhard
, p. 2679 - 2688 (2007/10/03)
Triflic anhydride reacts regioselectively with the ethoxy-carbonyl- substituted enaminones 6a-h to give the novel 3-trifloxypropene iminium salts 7a-d or iminium-substituted Δ2,3-butenolides 8a-d and 9a-d in good yields. Hydride reduction of the iminium salts 7a,b affords new 2-dialkylamino-4-trifloxy-but-3-enoates 13a,b, while mild hydrolysis generates 2-oxo-4-trifloxy-butenoates 14a,b. Butenolides 8b,d, and 9c react with methyl hydrazine to afford 4-dialkylamino-pyridazin-3(2H)-ones 12a-c.
