54972-26-8

Usage

Uses

Used in Pharmaceutical Industry:
Benzenesulfonamide, 4-methyl-N-(2-oxopropyl)is used as a sulfa drug for treating urinary tract infections and bacterial infections. Its application is based on its ability to inhibit the growth and reproduction of bacteria in the body, making it an effective treatment option.
Used in Chemical Synthesis:
Benzenesulfonamide, 4-methyl-N-(2-oxopropyl)is used as an intermediate in the synthesis of various pharmaceuticals and dyes. Its role in chemical synthesis is crucial for the production of a wide range of products in these industries.

Upstream product

• 1015-42-5 p-toluenesulfonyl-N-trimethylsilylamine 
• 70-55-3 toluene-4-sulfonamide 
• 1638623-48-9 N-(dimethyl(prop-1-en-2-yloxy)silyl)-4-methyl-N-(trimethylsilyl)benzenesulfonamide 
• 5997-56-8 4-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide 
• 50487-71-3 4-methyl-N-(2-propenyl)benzenesulfonamide 
• 55022-46-3 4-methyl-N-prop-2-ynylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 1616562-70-9 N-(2-azidoallyl)-4-methylbenzenesulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 76543-27-6 1-(p-toluenesulfonyl) azetidin-3-one 
• 75-87-6 chloral 
• 100-52-7 benzaldehyde 
• 941-55-9 4-toluenesulfonyl azide 
• 131713-53-6 N-(2,2-dimethoxypropyl)-4-methyl-N-<1-methyl-9-(phenylmethyl)-9H-carbazol-3-yl>methylbenzenesulphonamide 

Downstream Products

• 1088434-22-3 4-methyl-N-((2R,3S)-1-nitro-4-oxo-(thiophen-2-yl)entan-3-yl)lbenzenesulfonamide 
• 1088434-21-2 N-((2R,3S)-2-(benzo[d][1,3]dioxol-5-yl)-1-nitro-4-oxopentan-3-yl)-4-methylbenzenesulfonamide 
• 1088434-17-6 4-methyl-N-((2R,3S)-1-nitro-4-oxo-2-phenylpentan-3-yl)benzenesulfonamide 
• 1088434-20-1 N-((2R,3S)-2-(4-methoxyphenyl)-1-nitro-4-oxopentan-3-yl)-4-methylbenzenesulfonamide 
• 1088434-19-8 N-((2R,3S)-2-(4-chlorophenyl)-1-nitro-4-oxopentan-3-yl)-4-methylbenzenesulfonamide 
• 1088434-18-7 4-methyl-N-((2R,3S)-1-nitro-4-oxo-2-p-tolylpentan-3-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Experimental and computational evidence on gold-catalyzed regioselective hydration of phthalimido-protected propargylamines: An entry to β-amino ketones

The results of our investigations on the Au-catalyzed regioselective hydration reaction of both alkyl- A nd aryl-substituted N-propargyl phthalimides directed to the selective formation of the corresponding β-phthalimido ketones are described. Experimental data, in particular the observed regioselectivity, have been qualitatively supported by quantum-chemical calculations carried out on model systems in the framework of Density Functional Theory (DFT) followed by quantum theory of atoms in molecules (QTAIMS). Our results suggest that the electronic features of the initial adduct between the propargyl triple bond and the Au(i) catalyst, in particular the character of the gold-triple bond interaction, are essential for the observed regioselectivity. Other effects, such as the presence of the solvent and the formation of a H-bond between the water molecule and the phthalimido moiety, although apparently irrelevant for the regioselectivity, have proven to be kinetically and catalytically rather important. This journal is

CpTiCl2-Catalyzed Cross-Coupling between Internal Alkynes and Ketones: A Novel Concept in the Synthesis of Halogenated, Conjugated Dienes

A novel concept for the synthesis of halogenated, conjugated dienes is disclosed: the CpTiCl2-catalyzed coupling of keto-alkynes, in the presence of Me3SiBr/Et3N?HBr. This reaction provided five-, six-, and seven-membered

Nucleophilic Isomerization of Epoxides by Pincer-Rhodium Catalysts: Activity Increase and Mechanistic Insights

Herein, we present the efficient isomerization of epoxides into methyl ketones with a novel pincer-rhodium complex under very mild conditions. The catalyst system has an excellent functional group tolerance and a wide array of epoxides was tested. The corresponding methyl ketones were obtained in very high yields with excellent chemo- and regioselectivity. In addition, we investigated mechanistic details like the isomerization of the catalyst, and we obtained evidence that the catalytic cycle follows a β-hydride elimination-reductive elimination pathway after the nucleophilic ring opening of the epoxide.

Regio- and chemoselective rearrangement of terminal epoxides into methyl alkyl and aryl ketones

The development of the highly active pincer-type rhodium catalyst 2 for the nucleophilic Meinwald rearrangement of functionalised terminal epoxides into methyl ketones under mild conditions is presented. An excellent regio- and chemoselectivity is obtained for the first time for aryl oxiranes.

Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature

Several ppm level gold-catalyzed reactions enabled by the ligand HandaPhos can be performed at room temperature in aqueous nanoreactors composed of the surfactant Nok. Variously substituted allenes undergo cycloisomerization leading to heterocyclic products in good yields. Likewise, cyclodehydration is also illustrated under similar conditions, as is an intermolecular variant, hydration of terminal alkynes. Recycling of the catalyst and reaction medium is also illustrated. A low E factor associated with limited solvent use and therefore, waste generation, documents the greenness of this process.

Thiyl radical-mediated cyclization of ω-alkynyl O-tert-butyldiphenylsilyloximes

ω-Alkynyl O-tert-butyldiphenylsilyloximes, upon treatment with odorless 4-tert-butylbenzenethiol in the presence of azobisisobutyronitrile (AIBN) in refluxing benzene, underwent addition of a thiyl radical to the alkynyl group followed by radical cyclizat

Gold-Catalyzed Aminoalkenylation of β-Amino-1,n-Diynols to Cycloalkyl-, Piperidinyl- and Pyranyl-Fused Pyrroles

A synthetic method to prepare cycloalkyl-, piperidinyl- and pyranyl-fused pyrroles efficiently by gold(I)-catalyzed dehydrative aminoalkenylation of β-amino-1,n-diynols under mild conditions at room temperature is described.

Access to Polyfunctionalized Chiral Piperidines through Enantioselective Addition-Carbocyclization Cascade Reaction Catalyzed by a Rhodium(I)-Diene Complex

A new addition-carbocyclization cascade reaction initiated by arylboronic acids and catalyzed by a rhodium/chiral diene complex is described. Starting from N-bridged oxoenoate derivatives, highly functionalized piperidines bearing three contiguous stereogenic centers were obtained with excellent enantio- and diastereoselectivities.

Enantioselective organocatalytic michael/aldol sequence: Anticancer natural product (+)-trans-dihydrolycoricidine

A total synthesis of the anticancer natural product (+)-trans- dihydrolycoricidine is reported from α-azidoacetone and cinnamaldehyde precursors. Key elements include an asymmetric organocatalytic sequence proceeding by a regiospecific secondary-amine-catalyzed synMichael addition followed by an intramolecular aldol reaction. The sequence results in the formation of an advanced intermediate, containing three stereogenic centers, in one step which and was converted into the title compound in eight steps.

General silver-catalyzed hydroazidation of terminal alkynes by combining TMS-N3 and H2O: Synthesis of vinyl azides

A general hydroazidation of unactivated alkynes using silver catalysis is reported. The reactions of diverse terminal alkynes with trimethylsilyl azide (TMS-N3) in the presence of H2O afforded the corresponding vinyl azides in good to excellent yields. This reaction has a broad substrate scope, good functional group tolerance, simple operation, and high reaction efficiency, thus providing an easy access to various functionalized vinyl azides.