55153-14-5Relevant academic research and scientific papers
Palladium-Catalyzed Chemo- and Enantioselective C?O Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis
Chen, Jianzhong,Zhang, Zhenfeng,Liu, Delong,Zhang, Wanbin
supporting information, p. 8444 - 8447 (2016/07/19)
A chemoselective C?O bond cleavage of the ester alkyl side-chain of α-acyloxy ketones was realized for the first time by a highly efficient palladium-catalyzed hydrogenolysis (S/C=6000, the highest catalytic efficiency by far). Furthermore, a kinetic resolution of α-acyloxy ketones was first developed by enantioselective hydrogenolysis with good yields and up to 99 % ee.
Palladium-catalyzed asymmetric hydrogenation of α-acyloxy-1- arylethanones
Chen, Jianzhong,Liu, Delong,Butt, Nicholas,Li, Chao,Fan, Dongyang,Liu, Yangang,Zhang, Wanbin
supporting information, p. 11632 - 11636 (2013/11/06)
First hand: The first example of a palladium-catalyzed asymmetric hydrogenation of α-acyloxy ketones (1) was accomplished to give the hydrogenated products 2 with by far the highest catalytic efficiency in up to quantitative conversions and excellent enantioselectivities. The hydrogenated products could serve as important intermediates for the preparation of many drug candidates. TFE=2,2,2-trifluoroethanol. Copyright
Organic Reactions in Ionic Liquids: Ionic Liquid-Accelerated Nucleophilic Substitution Reaction of α-Tosyloxyketones with Potassium Salts of Aromatic Acids
Liu, Zhi,Chen, Zhen-Chu,Zheng, Qin-Guo
, p. 33 - 36 (2007/10/03)
The room temperature ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) is used as a 'green' recyclable alternative to classical molecular solvents for the nucleophilic substitution reaction of α-tosyloxy ketones with pota
A novel improved procedure for the synthesis of oxazoles
Huang, Wei,Pei, Jian,Chen, Bingzi,Pei, Weiwei,Ye, Xiulin
, p. 10131 - 10136 (2007/10/03)
In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2
Synthesis of phenacyl esters by using PTC and dibenzo-[18)-crown-6
Jugdale,Patil,Salunkhe
, p. 1747 - 1752 (2007/10/03)
In view of the importance of phenacyl esters as a protecting groups, a simple and efficient method is now reported here for synthesis of phenacyl esters in quantitative yield and high purity under mild reaction condition by using phase transfer catalyst a
CONVENIENT SYNTHESIS AND FACILE CLEAVAGE OF PHENACYL ESTERS
Huang, Zhizhen,Xie, Linghong,Huang, Xian
, p. 1167 - 1170 (2007/10/02)
A convenient synthesis of phenacyl esters and a facile cleavage of them with sodium hydrogen telluride are described.
Potential Hypolipidemic Agents: Part III - Synthesis and Hypolipidemic Activity of 4-(4,5-Substituted oxazol-2-yl)phenoxyalkanoic Acid Derivatives
Shridhar, D. R.,Ram, Bhagat,Sarma, C. R.,Thapar, G. S.,Krishnamurthy, A.
, p. 183 - 185 (2007/10/02)
A number of 4-(4,5-substituted oxazol-2-yl)phenoxyalkanoic acid derivatives have been synthesised and evaluated for their hypolipidemic activity.Ethyl 4-(4-p-chlorphenyl-5-methyloxazol-2-yl)phenoxyacetate (3) exhibits significant hypocholesterolemic and h
KINETICS OF REACTION OF TRIETHYLAMMONIUM CARBOXYLATES WITH α-HALOGENOCARBONYL COMPOUNDS IN ORGANIC SOLVENTS. REACTION OF BENZOATES AND PHENOXYACETATES WITH PHENACYL BROMIDE IN ACETONE
Pillay, M. Krishna,Kannan, K.,Ramasubramanian, P.
, p. 3899 - 3908 (2007/10/02)
The kinetics of the reaction of phenacyl bromide with triethylammonium p-substituted benzoates and phenoxyacetates at 25 deg C, 30 deg C and 35 deg C in acetone suggest a rigid cyclic transition state involving a hydrogen bonded ion-pair as the active nuc
