The Asymmetric Synthesis of 1-Alkyl-2,3,4,5-Tetrahydro-Benzazepines and Benzo-1-AzabicycloDecanes

Article abstract of DOI:10.1016/S0040-4020(01)80537-8

The metalation-alkylation of benzazepine formamidines gives high yields and good diastereoselectivity of 1-substituted derivatives.Removal of the chiral auxiliary leads to the title compounds in 84-96 percent ee and represents the first chiral benzazepine