5524-57-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl mesitylglyoxylate is used as a precursor in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs. Its unique chemical structure allows it to be a key component in the creation of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl mesitylglyoxylate is utilized as a starting material for the production of agricultural chemicals. Its role in the synthesis process aids in the development of effective pesticides and other agrochemicals designed to protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
Ethyl mesitylglyoxylate is used as a building block in the synthesis of other organic compounds, making it a valuable resource in organic chemistry research. Its versatility in forming esters and its reactivity in various chemical reactions contribute to the advancement of new chemical processes and the discovery of novel organic compounds.
Used in Academic and Industrial Settings:
As a compound of interest for scientists and researchers, ethyl mesitylglyoxylate is employed in both academic research laboratories and industrial settings. Its potential applications in creating valuable products drive the exploration of innovative chemical processes and the development of new technologies in the fields of pharmaceuticals, agrochemicals, and organic chemistry.

InChI:InChI=1/C13H16O3/c1-5-16-13(15)12(14)11-9(3)6-8(2)7-10(11)4/h6-7H,5H2,1-4H3

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 95-92-1 oxalic acid diethyl ester 
• 2633-66-1 2-mesitylmagnesium bromide 
• 6957-89-7 Ethyl dichloro-(ethoxy)-acetate 
• 7446-70-0 aluminium trichloride 
• 60-29-7 diethyl ether 
• 66150-50-3 ethyl 2-hydroxy-2-mesitylacetate 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 57386-83-1 1,3-dichloro-2,4,6-trimethylbenzene 
• 1667-04-5 2-bromomesitylene 

Downstream Products

• 4746-81-0 mesitil 
• 85905-78-8 Triethylsilanyloxy-(2,4,6-trimethyl-phenyl)-acetic acid ethyl ester 
• 85905-82-4 (Dibutyl-ethyl-silanyloxy)-(2,4,6-trimethyl-phenyl)-acetic acid ethyl ester 
• 85905-86-8 Triisobutylsilanyloxy-(2,4,6-trimethyl-phenyl)-acetic acid ethyl ester 
• 1196988-55-2 C₁₃H₁₈O₃ 
• 1251859-36-5 C₁₆H₂₂O₃ 
• 925-93-9 ethyl [2]alcohol 
• 1402841-31-9 (E)-ethyl 2-mesityl-2-((trimethylsilyl)methylimino)acetate 
• 5796-78-1 α-mesityl-2,4,6-trimethylacetophenone 
• 3112-46-7 mesitylglyoxylic acid 

Relevant academic research and scientific papers

Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

Reactions of functionalized aryllithiums with dialkyl oxalates were achieved using a flow microreactor to obtain α-keto esters with high selectivity by virtue of fast 1:1 micromixing.

Aryllithiums with increasing steric crowding and lipophilicity prepared from chlorides in diethyl ether. the first directly prepared room-temperature-stable dilithioarenes

A convenient procedure has been developed for the preparation of synthetically useful, room-temperature-stable aryllithiums starting from aryl chlorides and lithium metal. The method provides a route to aryllithiums which have previously not been accessible cleanly or could only be prepared by using more expensive starting materials.

Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee).

CeCl3·7H2O: An effective additive in ru-catalyzed enantioselective hydrogenation of aromatic α-ketoesters

(Chemical Equation Presented) In the presence of catalytic amounts of CeCl3·7H2O, [RuCl(benzene)(S)-SunPhos]Cl is a highly effective catalyst for the asymmetric hydrogenation of aromatic α-ketoesters. A variety of ethyl α-hydroxy-α-arylacetates have been prepared in up to 98.3% ee with a TON up to 10 000. Challenging aromatic α-ketoesters with ortho substituents are also hydrogenated with high enantioselectivities. The addition of CeCl3·7H2O not only improves the enantioselectivity but also enhances the stability of the catalyst. The ratio of CeCl3·7H2O to [RuCl(benzene)(S)-SunPhos]Cl plays an important role in the hydrogenation reaction with a large substrate/catalyst ratio.

AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES

Pyrimidines and triazines of formula (I) wherein R is C 1-6alkyl, amino, mono-or diC 1-6alkylamino; R 1 is hydrogen, C 1-6alkyl, C 3-6alkenyl, hydroxyC 1-6alkyl or C 1-6alkyloxy-C 1-6alkyl; R 2 is C 1-6alkyl, mono-or diC 3-6cycloalkylmethyl, phenylmethyl, substituted phenylmethyl, C 1-6alkyloxy-C 1-6alkyl, hydroxyC 1-6alkyl, C 1-6alkyloxycarbonylC 1-6alkyl, C 3-6alkenyl; or R 1 and R 2 taken together with the nitrogen to which they are attached may form a pyrrolidinyl, morpholinyl or piperidinyl group; X is N or CR 3; R 3 is hydrogen or C 1-6alkyl; R 4 is phenyl or substituted phenyl; A is or--CR 7R 8--wherein R 5 and R 6 each independently are hydrogen or C 1-4alkyl; R 7 is hydrogen or OH, R 8 is hydrogen or C 1-6alkyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing these compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

Syntheses of Aryl Glyoxylate. I. The Reaction of Alkyl Dichloro(alkoxy)acetates with Aromatics in the Presence of Lewis Acid

Ethyl dichloro(ethoxy)acetate(1) and methyl dichloro(methoxy)acetate(2) were characterized.The reaction of 1 and 2 with aromatics in the presence of AlCl3 gave a considerable yield of aromatic α-keto ester.The aromatics included mono- and polymethylbenzene and anisol.The reaction was studied under various conditions and the results were compared with the acylation by ethoxalyl or methoxalyl chloride.The reaction mechanism was also discussed.