5536-30-1

Basic information

• Product Name: 5-AMINO-2'-DEOXYURIDINE FREE BASE
• Synonyms: 5-AMINO-2'-DEOXYURIDINE FREE BASE;5-Amino-dUrd;5-Aminodeoxyuridine
• CAS NO: 5536-30-1
• Molecular Formula: C₉H₁₃N₃O₅
• Molecular Weight: 243.218
• EINECS: 226-894-4
• Mol File: 5536-30-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-AMINO-2'-DEOXYURIDINE FREE BASE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2'-DEOXYURIDINE FREE BASE(5536-30-1)
• EPA Substance Registry System: 5-AMINO-2'-DEOXYURIDINE FREE BASE(5536-30-1)

Safety Data

• Hazardous Substances Data: 5536-30-1(Hazardous Substances Data)

Usage

General Description

5-Amino-2'-deoxyuridine free base is a chemical compound that belongs to the uridine group of nucleosides. It is a modified form of uridine, a key component of RNA molecules, and is commonly used for research purposes in biochemistry and molecular biology. 5-AMINO-2'-DEOXYURIDINE FREE BASE contains an amino group and a deoxyribose sugar, and it plays a role in the synthesis and modification of nucleic acids. 5-Amino-2'-deoxyuridine free base is often used as a biochemical tool for studying RNA editing and for investigating the structure and function of RNA molecules. Additionally, it has potential therapeutic applications in the treatment of certain genetic disorders and viral infections.

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Relevant articles and documents

Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation

Green fluorescent protein (GFP)-based molecular-rotor chromophores were attached to the 5-positions of deoxyuridines, and subsequently, incorporated into the middle positions of oligodeoxynucleotides. These oligonucleotides were designed to form triplex D

EFFECT OF C5-AMINO SUBSTITUENT ON 2'-DEOXYURIDINE BASE PAIRING WITH 2'-DEOXYADENOSINE: INVESTIGATION BY 1H AND 13C NMR SPECTROSCOPY

Substituents at 5-position of a pyrimidine base are known to affect its base pairing properties with complementary purines, either by altering the imino N3-H acidity or by modifying the acceptor strength of C2 and C4 carbonyls.This paper reports comparative base pair property of 5-methyl-2'-deoxyuridine (dT) and 5-amino-2'-deoxyuridine (dUNH2) with 2'-deoxyadenosine (dA) as their 3',5'-di-t-butyldimethylsilyl derivatives in chloroform-d.Using 1H and 13C NMR, it is demonstrated that the 5-NH2 substituent in 2'-deoxyuridine results in (i) decreased association (lower Ka) with 2'-deoxyadenosine compared to dA:dT complexation and (ii) increased receptor strength of C2 carbonyl compared to C4 carbonyl and (iii) lower temperature for separation of 6-amino protons of dA due to its complexation with dUNH2 compared to that with dT.

Importance of 3′-hydroxyl group of the nucleosides for the reactivity of thymidine phosphorylase from Escherichia coli

Thymidine phosphorylase in phosphate buffer catalyzed the conversion of thymidine to unnatural nucleosides. The 3′-OH, but not the 5′-OH of ribosyl moiety is necessary to be recognized as a substrate. Thus 3′-deoxythymidine could not convert to 5-fluorouracil-2′,3′- dideoxyribose. However, 5′-deoxythymidine was converted to 5-fluorouracil-2′,5′-dideoxyribose. Copyright