55419-66-4

Basic information

• Product Name: TRIFLUORO-ACETIC ACID PHENETHYL ESTER
• Synonyms: TRIFLUORO-ACETIC ACID PHENETHYL ESTER;Acetic acid, 2,2,2-trifluoro-, 2-phenylethyl ester;Phenethyl 2,2,2-trifluoroacetate
• CAS NO: 55419-66-4
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.1724696
• Mol File: 55419-66-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 225.6°C at 760 mmHg
• Flash Point: 72.9°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 0.0857mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: TRIFLUORO-ACETIC ACID PHENETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUORO-ACETIC ACID PHENETHYL ESTER(55419-66-4)
• EPA Substance Registry System: TRIFLUORO-ACETIC ACID PHENETHYL ESTER(55419-66-4)

Safety Data

• Hazardous Substances Data: 55419-66-4(Hazardous Substances Data)

Usage

General Description

TRIFLUORO-ACETIC ACID PHENETHYL ESTER is a chemical compound that is derived from trifluoroacetic acid and phenethyl alcohol. It has potential applications in the pharmaceutical and agrochemical industries due to its unique properties. This ester is known for its strong acidity and is commonly used as a reagent in organic synthesis. Its trifluoromethyl group adds stability and enhances the chemical properties of the compound. TRIFLUORO-ACETIC ACID PHENETHYL ESTER is a versatile compound that can be utilized in various chemical reactions and processes, making it a valuable tool for research and development in different fields.

InChI:InChI=1/C10H9F3O2/c11-10(12,13)9(14)15-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2

Upstream product

• 60-12-8 2-phenylethanol 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 51751-79-2 2-Phenylaethylmenasylat 
• 24760-80-3 2-phenylethyl p-nitrobenzenesulphonate 
• 100-42-5 styrene 

Downstream Products

• 75-89-8 2,2,2-trifluoroethanol 
• 60-12-8 2-phenylethanol 
• 146039-09-0 Phenethyl-phosphorimidic acid triethyl ester 
• 53050-54-7 phenethylamine; toluene-4-sulfonate 
• 100-41-4 ethylbenzene 
• 6926-44-9 phenethyl azide 

Relevant articles and documents

ION PAIRS IN TRIFLUOROACETOLYSIS OF 2-ARYLETHYL ARENESULFONATES

The behaviour of ion pairs in the trifluoroacetolysis of 2-arylethyl arenesulfonates was studied by means of tracer techniques with deuterium and oxygen-18

Synthesis and evaluation of the antioxidant activity of lipophilic phenethyl trifluoroacetate esters by in vitro ABTS, DPPH and in cell-culture DCF assays

Polyphenols are natural compounds showing a variety of health-promoting effects. Unfortunately, due to low lipid solubility, their applications in the pharmaceutical, food, and cosmetic industries are limited. With the aim of obtaining novel lipophilic derivatives, the present study reports the synthesis of a series of phenethyl trifluoroacetate esters containing up to two hydroxyl groups in the aromatic ring. Experimental logP values confirmed a greater lipophilicity of the novel compounds compared to the parent compounds. The radical scavenging capacity of all phenethyl trifluoroacetate esters was evaluated by in vitro assays (ABTS, DPPH) and in cultured cells (L6 myoblasts and THP-1 leukemic monocytes) using 2,7-dichlorodihydrofluorescein diacetate. These data revealed that the esters showed a good antioxidant effect that was strictly dependent on the grade of hydroxylation of the phenyl ring. The lack of toxicity, evaluated by the MTT assay and proliferation curves, makes these trifluoroacetates attractive derivatives for pharmaceutical, food, and cosmetic applications.

Nucleophilic acyl substitutions of anhydrides with protic nucleophiles catalyzed by amphoteric, oxomolybdenum species

(Chemical Equation Presented) Among six different group VIb oxometallic species examined, dioxomolybdenum dichloride and oxomolybdenum tetrachloride were the most efficient catalysts to facilitate nucleophilic acyl substitution (NAS) of anhydrides with a myriad array of alcohols, amines, and thiols in high yields and high chemoselectivity. In contrast to the well-recognized redox chemical behaviors associated with oxomolybdenum(VI) species, the catalytic NAS was unprecedented and tolerates virtually all kinds of functional groups. By using benzoic anhydride as a mediator for in situ generation of an incipient mixed anhydride-MoO2Cl2 adduct with a given functional alkanoic acid, one can achieve oleate, dipeptide, diphenylmethyl, N-Fmoc-α-amino, pyruvic, and tert-butylthio ester, N-tert-butylamide, and trityl methacrylate syntheses with appropriate protic nucleophiles. The amphoteric character of the Mo=O unit in oxomolybdenum chlorides was found to be responsible for the catalytic NAS profile as supported by a control NAS reaction of using an authentic adduct-MoOCl2(O2-CBu t)2 between pivalic anhydride and MoO2Cl 2 as the catalyst.

TRIETHYL PHOSPHITE IN ORGANIC SYNTHESIS. A FACILE, ONE-POT CONVERSION OF ALCOHOLS INTO AMINES

General protocols for converting primary, secondary, and tertiary alcohols into the corresponding primary amines are presented.