5658-61-7

Basic information

• Product Name: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE
• Synonyms: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE;2-(4-CHLOROPHENOXY)-2-METHYLPROPIONAMIDE
• CAS NO: 5658-61-7
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66
• Mol File: 5658-61-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 126℃
• Boiling Point: 373.3°Cat760mmHg
• Flash Point: 179.6°C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 9.05E-06mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE(5658-61-7)
• EPA Substance Registry System: 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE(5658-61-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 5658-61-7(Hazardous Substances Data)

Usage

General Description

2-(4-chlorophenoxy)-2-methylpropanamide is a chemical compound that belongs to the class of amides. It is a white or off-white crystalline solid that is commonly used in the synthesis of pharmaceuticals and agricultural chemicals. 2-(4-CHLOROPHENOXY)-2-METHYLPROPANAMIDE is derived from 4-chlorophenol and 2-methylpropionyl chloride. It is known for its potential as an anti-inflammatory agent, and it has shown promise in preclinical studies for the treatment of certain types of cancers. However, more research is needed to fully understand the potential medical applications and potential side effects of 2-(4-chlorophenoxy)-2-methylpropanamide.

InChI:InChI=1/C10H12ClNO2/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H2,12,13)

Upstream product

• 1193-00-6 sodium 4-chlorophenolate 
• 882-09-7 Clofibric acid 
• 7462-74-0 2-bromo-2-methylpropanamide 
• 106-48-9 4-chloro-phenol 
• 5542-60-9 clofibryl chloride 

Downstream Products

• 106-47-8 4-chloro-aniline 
• 124188-17-6 2-(4-chloro-2-nitrophenoxy)-2-methylpropanoic acid 
• 124188-36-9 2-hydroxy-2-methyl-N-(4-chloro-2-nitrophenyl)propionamide 
• 124188-37-0 6-chloro-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 88222-08-6 1-carbamoil-2-(4-clorofenossi)-2-metilpropilammina 
• 88222-07-5 acetil-2-(4-clorofenossi)-2-metilpropilammina 
• 69846-08-8 1-nicotinoil-2-(4-clorofenossi)-2-metilpropilammine 
• 22786-73-8 2-(4-Chloro-phenoxy)-N-hydroxymethyl-2-methyl-propionamide 
• 124188-20-1 2-(4-chloro-2-nitrophenoxy)-2-methylpropanamide 
• 62100-41-8 α-hydroxy-isobutyric acid-(4-chloro-anilide) 

Relevant articles and documents

Facilitated transport of two model steroids by esters and amides of clofibric acid

A series of novel dermal penetration enhancers, esters and amides of clofibric acid, was synthesized. The permeation parameters and skin retention of two steroids (hydrocortisone-21-acetate and betamethasone-17-valerate) in propylene glycol were studied with athymic nude mouse skin by in vitro diffusion cell techniques in the presence of the novel enhancer compounds. Isopropyl myristate, dimethyl lauramide, and 1-dodecylazacycloheptan-2-one (laurocapram, Azone) were used as control enhancers. The most satisfactory enhancement of both the ester and amide series was observed with clofibric acid octyl amide; coadministration increased skin retention of hydrocortisone acetate after 24 h by 3.5-fold and that of betamethasone valerate by 2.9- fold. Diffusion cell receptor concentrations increased 51.6- and 10.3-fold, respectively, during the same time period. However, the enhancer compound in this case was applied to the skin 1 h prior to each of the steroids. The amide analogues were more effective than the equivalent ester compounds of the same carbon chain length. The best enhancer compounds (2c, 3d, 3e, and 3f) were nonirritating to athymic mouse skin in vivo.

ipso Nitration in p-halophenyl ethers

Addition of nitronium ion ipso to halogen occurs on nitration of the p-haloanisoles in acetic anhydride at -60 deg C.In the cases of p-fluoro- and p-chloro-anisole, addition of the nitronium ion is reversible and only small amounts of ipso products are obtained.With p-bromoanisole nitrodebromination occurs.When p-halophenyl ethers containing a trapping substituent, e.g., 2-(4-chlorophenoxy)-2-methylpropanoic acid, are used as substrates, substantial amounts of the spiro diene with nitro ipso to halogen, e.g., 3,3-dimethyl-8-chloro-8-nitro-1,4-dioxaspirodeca-6,9-dien-2-one, can be isolated.The results demonstrate that extensive ipso attack at the halogen-substituted position is general in the nitration of p-halophenyl ethers.Key words: ipso nitration, ether, diene, p-haloanisole.